| Inflammation and the mental state before an acute coronary event. | |
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MedLine Citation:
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PMID: 10342499 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Feelings of exhaustion have been found to belong to the precursors of acute coronary events. Guided by the current views of the pathogenesis of acute coronary syndromes, a two-stage model describing a feedback relationship between mental state and the disease process is presented. According to the presented model prolonged exposure to stress results in a state of exhaustion leading to increased susceptibility to inflammatory diseases. Inflammation, in turn, amplifies feelings of exhaustion and malaise through cytokine release. Results of a study of 15 exhausted and 15 nonexhausted angioplasty patients, showing elevated levels of interleukin-1beta and tumour necrosis factor-alpha in the exhausted patients, give empirical support to this model. |
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Authors:
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A Appels |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of medicine Volume: 31 Suppl 1 ISSN: 0785-3890 ISO Abbreviation: Ann. Med. Publication Date: 1999 Apr |
Date Detail:
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Created Date: 1999-07-08 Completed Date: 1999-07-08 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8906388 Medline TA: Ann Med Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 41-4 Citation Subset: IM |
Affiliation:
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Department of Medical Psychology, University of Maastricht, The Netherlands. ad.appels@mp.unimaas.nl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Case-Control Studies Coronary Disease / etiology, psychology* Cytokines / metabolism* Fatigue / complications* Humans Inflammation / complications* Models, Cardiovascular Risk Factors Stress, Psychological / complications* |
| Chemical | |
Reg. No./Substance:
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0/Cytokines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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