Document Detail

Inflammation markers in young post-myocardial patients exhibiting various expressions of classic coronary risk factors.
MedLine Citation:
PMID:  16707954     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We investigated inflammation markers in young post-myocardial infarction patients exhibiting various expressions of classical risk factors. METHODS: Forty-one male patients with high (n=20) and low (n=21) expression of classical risk factors (risk of coronary events calculated by the prospective cardiovascular Munster study program high or low, respectively), on average 44 years old, who were in the stable phase after myocardial infarction (on average 20.5 months after myocardial infarction) were included in the study. The control group consisted of 25 healthy, age-matched men. The following inflammation markers were measured: leukocyte count, high-sensitive C-reactive protein, interleukin-6, tumor necrosis factor-alpha, intracellular adhesion molecule-1, vascular cellular adhesion molecule-1, selectin-P and selectin-E. RESULTS: No differences in the levels of leukocytes, high-sensitive C-reactive protein, tumor necrosis factor-alpha, intracellular adhesion molecule-1, vascular cellular adhesion molecule-1, selectin-P and selectin-E were found between the group of patients and the controls. In contrast, interleukin-6 was significantly (P<0.01) elevated in the group of patients with high [2.5 (1.9-5.3) ng/ml] and low [3.2 (1.5-8.4) ng/ml] expression of risk factors compared with the controls [1.4 (0.9-2.3) ng/ml]. Significantly, there was no difference in interleukin-6 between the two groups of patients. CONCLUSIONS: We did not find differences in inflammation markers between young post-myocardial infarction patients with or without classical risk factors. Thus, it seems that the presence of (treated) risk factors or their absence does not affect the levels of inflammation markers in the stable period after myocardial infarction. Importantly, we found similarly elevated interleukin-6 in both groups of patients, most probably indicating slight local vascular inflammation. Interleukin-6 appears to be the most suitable marker of vascular inflammation in post-myocardial infarction patients who are aggressively treated pharmacologically.
Barbara Erzen; Miso Sabovic; Pavel Poredos; Miran Sebestjen; Irena Keber; Sasa Simcic
Related Documents :
9241754 - The leu33/pro polymorphism (pla1/pla2) of the glycoprotein iiia (gpiiia) receptor is no...
11485024 - Interleukin-6 gene polymorphisms and susceptibility to myocardial infarction: the ectim...
20625114 - Prospective study of obstructive sleep apnea and incident coronary heart disease and he...
12824724 - Estrogen receptor dinucleotide (ta) polymorphism does not predict premature myocardial ...
1347484 - Internal mammary artery angiography should be a routine component of diagnostic coronar...
22078394 - Comparison of heart-type fatty acid binding protein and sensitive troponin for the diag...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Coronary artery disease     Volume:  17     ISSN:  0954-6928     ISO Abbreviation:  Coron. Artery Dis.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-05-18     Completed Date:  2006-11-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9011445     Medline TA:  Coron Artery Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  325-30     Citation Subset:  IM    
Department of Vascular Disease, University Medical Centre, Ljubljana, Slovenia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Biological Markers / analysis*
C-Reactive Protein / analysis
Case-Control Studies
Coronary Disease / etiology*
E-Selectin / blood
Inflammation / diagnosis,  metabolism*
Intercellular Adhesion Molecule-1 / blood
Interleukin-6 / blood
Leukocyte Count
Myocardial Infarction / complications*
P-Selectin / blood
Risk Factors
Tumor Necrosis Factor-alpha / analysis
Vascular Cell Adhesion Molecule-1 / blood
Reg. No./Substance:
0/Biological Markers; 0/E-Selectin; 0/Interleukin-6; 0/P-Selectin; 0/TNF protein, human; 0/Tumor Necrosis Factor-alpha; 0/Vascular Cell Adhesion Molecule-1; 126547-89-5/Intercellular Adhesion Molecule-1; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Falls in hospitalized patients: can nursing information systems data predict falls?
Next Document:  Carotid intima-media thickness in coronary slow flow: relationship with plasma homocysteine levels.