| Inflammation markers in young post-myocardial patients exhibiting various expressions of classic coronary risk factors. | |
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MedLine Citation:
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PMID: 16707954 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: We investigated inflammation markers in young post-myocardial infarction patients exhibiting various expressions of classical risk factors. METHODS: Forty-one male patients with high (n=20) and low (n=21) expression of classical risk factors (risk of coronary events calculated by the prospective cardiovascular Munster study program high or low, respectively), on average 44 years old, who were in the stable phase after myocardial infarction (on average 20.5 months after myocardial infarction) were included in the study. The control group consisted of 25 healthy, age-matched men. The following inflammation markers were measured: leukocyte count, high-sensitive C-reactive protein, interleukin-6, tumor necrosis factor-alpha, intracellular adhesion molecule-1, vascular cellular adhesion molecule-1, selectin-P and selectin-E. RESULTS: No differences in the levels of leukocytes, high-sensitive C-reactive protein, tumor necrosis factor-alpha, intracellular adhesion molecule-1, vascular cellular adhesion molecule-1, selectin-P and selectin-E were found between the group of patients and the controls. In contrast, interleukin-6 was significantly (P<0.01) elevated in the group of patients with high [2.5 (1.9-5.3) ng/ml] and low [3.2 (1.5-8.4) ng/ml] expression of risk factors compared with the controls [1.4 (0.9-2.3) ng/ml]. Significantly, there was no difference in interleukin-6 between the two groups of patients. CONCLUSIONS: We did not find differences in inflammation markers between young post-myocardial infarction patients with or without classical risk factors. Thus, it seems that the presence of (treated) risk factors or their absence does not affect the levels of inflammation markers in the stable period after myocardial infarction. Importantly, we found similarly elevated interleukin-6 in both groups of patients, most probably indicating slight local vascular inflammation. Interleukin-6 appears to be the most suitable marker of vascular inflammation in post-myocardial infarction patients who are aggressively treated pharmacologically. |
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Authors:
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Barbara Erzen; Miso Sabovic; Pavel Poredos; Miran Sebestjen; Irena Keber; Sasa Simcic |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Coronary artery disease Volume: 17 ISSN: 0954-6928 ISO Abbreviation: Coron. Artery Dis. Publication Date: 2006 May |
Date Detail:
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Created Date: 2006-05-18 Completed Date: 2006-11-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9011445 Medline TA: Coron Artery Dis Country: England |
Other Details:
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Languages: eng Pagination: 325-30 Citation Subset: IM |
Affiliation:
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Department of Vascular Disease, University Medical Centre, Ljubljana, Slovenia. erzen_b@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Markers / analysis* C-Reactive Protein / analysis Case-Control Studies Coronary Disease / etiology* E-Selectin / blood Humans Inflammation / diagnosis, metabolism* Intercellular Adhesion Molecule-1 / blood Interleukin-6 / blood Leukocyte Count Male Myocardial Infarction / complications* P-Selectin / blood Risk Factors Tumor Necrosis Factor-alpha / analysis Vascular Cell Adhesion Molecule-1 / blood |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/E-Selectin; 0/Interleukin-6; 0/P-Selectin; 0/TNF protein, human; 0/Tumor Necrosis Factor-alpha; 0/Vascular Cell Adhesion Molecule-1; 126547-89-5/Intercellular Adhesion Molecule-1; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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