| Inflammation markers in patients with coronary artery disease--comparison of intracoronary and systemic levels. | |
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MedLine Citation:
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PMID: 20517668 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND AIM: Raised levels of inflammation markers are associated with worse prognosis in patients with coronary artery disease. It is generally believed, although it has never been proven, that inflammation markers are released from (un)stable plaques in coronary arteries. We investigated this issue by directly comparing levels of inflammation markers in coronary and systemic blood. PATIENTS AND METHODS: Patients with acute coronary syndrome (N = 11), stable angina pectoris (N = 10) and controls with noncoronary origin of chest pain (N = 9) were included in the study. Intracoronary blood samples were taken at the culprit lesion in the coronary artery in patients with acute coronary syndrome and from any coronary artery in the other two groups, together with systemic blood samples from the femoral vein and artery. Levels of high-sensitivity C reactive protein (hsCRP), interleukin 6, interleukin 8, interleukin 10, soluble receptor for interleukin 2 (tR IL-2) and myeloperoxidase were measured in all samples. RESULTS: We found significantly elevated levels of hsCRP and interleukin 10 in patients with acute coronary syndrome compared with patients with stable angina and the control patients. Notably, we did not find any difference between intracoronary and systemic levels of any inflammatory marker in patients with acute coronary syndrome. Furthermore, no difference between intracoronary and systemic levels of markers was present in patients with stable angina or in the control group. CONCLUSIONS: We observed that excess circulating inflammation markers, being characteristic of unstable coronary artery disease, are released from noncoronary sources. Thus, it may be speculated that systemic inflammation precedes local inflammation at the plaques, thereby transforming coronary disease from a stable to an unstable form. |
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Authors:
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Simona Kirbis; Urska D Breskvar; Miso Sabovic; Igor Zupan; Andreja Sinkovic |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Wiener klinische Wochenschrift Volume: 122 Suppl 2 ISSN: 1613-7671 ISO Abbreviation: Wien. Klin. Wochenschr. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-06-02 Completed Date: 2010-10-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 21620870R Medline TA: Wien Klin Wochenschr Country: Austria |
Other Details:
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Languages: eng Pagination: 31-4 Citation Subset: IM |
Affiliation:
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Department of Intensive Care Unit, University Clinical Center Maribor, Maribor, Slovenia. simona.kirbis@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Coronary Syndrome
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blood,
therapy Aged Angina Pectoris / blood, therapy Angioplasty, Transluminal, Percutaneous Coronary C-Reactive Protein / metabolism Coronary Angiography Coronary Artery Disease / blood*, therapy Coronary Vessels / metabolism Female Heart Catheterization Humans Inflammation Mediators / blood* Interleukin-10 / blood Interleukin-6 / blood Interleukin-8 / blood Male Middle Aged Myocardial Infarction / pathology Peroxidase / blood Prognosis Receptors, Interleukin-2 / blood Reference Values |
| Chemical | |
Reg. No./Substance:
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0/Inflammation Mediators; 0/Interleukin-6; 0/Interleukin-8; 0/Receptors, Interleukin-2; 130068-27-8/Interleukin-10; 9007-41-4/C-Reactive Protein; EC 1.11.1.7/Peroxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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