Document Detail

Inflammation markers in patients with coronary artery disease--comparison of intracoronary and systemic levels.
MedLine Citation:
PMID:  20517668     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND AIM: Raised levels of inflammation markers are associated with worse prognosis in patients with coronary artery disease. It is generally believed, although it has never been proven, that inflammation markers are released from (un)stable plaques in coronary arteries. We investigated this issue by directly comparing levels of inflammation markers in coronary and systemic blood. PATIENTS AND METHODS: Patients with acute coronary syndrome (N = 11), stable angina pectoris (N = 10) and controls with noncoronary origin of chest pain (N = 9) were included in the study. Intracoronary blood samples were taken at the culprit lesion in the coronary artery in patients with acute coronary syndrome and from any coronary artery in the other two groups, together with systemic blood samples from the femoral vein and artery. Levels of high-sensitivity C reactive protein (hsCRP), interleukin 6, interleukin 8, interleukin 10, soluble receptor for interleukin 2 (tR IL-2) and myeloperoxidase were measured in all samples. RESULTS: We found significantly elevated levels of hsCRP and interleukin 10 in patients with acute coronary syndrome compared with patients with stable angina and the control patients. Notably, we did not find any difference between intracoronary and systemic levels of any inflammatory marker in patients with acute coronary syndrome. Furthermore, no difference between intracoronary and systemic levels of markers was present in patients with stable angina or in the control group. CONCLUSIONS: We observed that excess circulating inflammation markers, being characteristic of unstable coronary artery disease, are released from noncoronary sources. Thus, it may be speculated that systemic inflammation precedes local inflammation at the plaques, thereby transforming coronary disease from a stable to an unstable form.
Simona Kirbis; Urska D Breskvar; Miso Sabovic; Igor Zupan; Andreja Sinkovic
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Wiener klinische Wochenschrift     Volume:  122 Suppl 2     ISSN:  1613-7671     ISO Abbreviation:  Wien. Klin. Wochenschr.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-06-02     Completed Date:  2010-10-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  21620870R     Medline TA:  Wien Klin Wochenschr     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  31-4     Citation Subset:  IM    
Department of Intensive Care Unit, University Clinical Center Maribor, Maribor, Slovenia.
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MeSH Terms
Acute Coronary Syndrome / blood,  therapy
Angina Pectoris / blood,  therapy
Angioplasty, Transluminal, Percutaneous Coronary
C-Reactive Protein / metabolism
Coronary Angiography
Coronary Artery Disease / blood*,  therapy
Coronary Vessels / metabolism
Heart Catheterization
Inflammation Mediators / blood*
Interleukin-10 / blood
Interleukin-6 / blood
Interleukin-8 / blood
Middle Aged
Myocardial Infarction / pathology
Peroxidase / blood
Receptors, Interleukin-2 / blood
Reference Values
Reg. No./Substance:
0/Inflammation Mediators; 0/Interleukin-6; 0/Interleukin-8; 0/Receptors, Interleukin-2; 130068-27-8/Interleukin-10; 9007-41-4/C-Reactive Protein; EC

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