Document Detail

Inflammation induces serine protease inhibitor 3 expression in the rat pineal gland.
MedLine Citation:
PMID:  12127095     Owner:  NLM     Status:  MEDLINE    
In the rat pineal gland, prominent expression of serine protease inhibitor 3 (SPI-3) mRNA is seen after systemic injection of lipopolysaccharide. The up-regulation of SPI-3 mRNA expression is also confirmed by northern blotting. Most SPI-3 mRNA-positive cells simultaneously express synaptophysin, a marker for pinealocytes, but not glial fibrillary acidic protein, a marker for astrocytes. This indicates that SPI-3 mRNA-positive cells are pinealocytes. Almost all SPI-3 mRNA-positive cells also showed translocation of the signal transducers and activators of transcription 3 (STAT3) into nuclei after lipopolysaccharide injection. These data support previous in vitro results that SPI-3 expression is induced in a STAT3-mediated manner. In addition, the expression of ciliary neurotrophic factor receptor (CNTFR) and leukemia inhibitory factor receptor (LIFR) mRNAs, but not of interleukin 6 receptor mRNA, was up-regulated after systemic lipopolysaccharide treatment. Because these receptors are upstream of STAT3, the present results suggest that cytokines such as LIF and/or CNTF induce SPI-3 expression via STAT3 in the pineal gland in response to inflammatory stimulus. We conclude that although the functional consequences of SPI-3 in the pineal gland during systemic inflammation are unknown, SPI-3 may have a crucial role in preventing some degenerative proteolysis induced by inflammatory stimuli.
A Takamiya; M Takeda; A Yoshida; H Kiyama
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuroscience     Volume:  113     ISSN:  0306-4522     ISO Abbreviation:  Neuroscience     Publication Date:  2002  
Date Detail:
Created Date:  2002-07-19     Completed Date:  2002-09-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7605074     Medline TA:  Neuroscience     Country:  United States    
Other Details:
Languages:  eng     Pagination:  387-94     Citation Subset:  IM    
Copyright Information:
Copyright 2002 IBRO
Department of Anatomy, Asahikawa Medical College, 2-1 Midorigaoka Higashi Asahikawa, Hokkaido 078-8510, Japan.
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MeSH Terms
Acute-Phase Proteins / genetics,  metabolism*
DNA-Binding Proteins / metabolism
Inflammation / metabolism*
Leukemia Inhibitory Factor Receptor alpha Subunit
Lipopolysaccharides / pharmacology
Pineal Gland / cytology,  drug effects,  metabolism*
RNA, Messenger / metabolism
Rats, Wistar
Receptor, Ciliary Neurotrophic Factor / genetics
Receptors, Cytokine / genetics
Receptors, OSM-LIF
STAT3 Transcription Factor
Trans-Activators / metabolism
Reg. No./Substance:
0/Acute-Phase Proteins; 0/DNA-Binding Proteins; 0/Leukemia Inhibitory Factor Receptor alpha Subunit; 0/Lifr protein, rat; 0/Lipopolysaccharides; 0/RNA, Messenger; 0/Receptor, Ciliary Neurotrophic Factor; 0/Receptors, Cytokine; 0/Receptors, OSM-LIF; 0/STAT3 Transcription Factor; 0/Serpina3n protein, rat; 0/Serpins; 0/Stat3 protein, rat; 0/Trans-Activators

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