| Inflammation induces serine protease inhibitor 3 expression in the rat pineal gland. | |
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MedLine Citation:
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PMID: 12127095 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the rat pineal gland, prominent expression of serine protease inhibitor 3 (SPI-3) mRNA is seen after systemic injection of lipopolysaccharide. The up-regulation of SPI-3 mRNA expression is also confirmed by northern blotting. Most SPI-3 mRNA-positive cells simultaneously express synaptophysin, a marker for pinealocytes, but not glial fibrillary acidic protein, a marker for astrocytes. This indicates that SPI-3 mRNA-positive cells are pinealocytes. Almost all SPI-3 mRNA-positive cells also showed translocation of the signal transducers and activators of transcription 3 (STAT3) into nuclei after lipopolysaccharide injection. These data support previous in vitro results that SPI-3 expression is induced in a STAT3-mediated manner. In addition, the expression of ciliary neurotrophic factor receptor (CNTFR) and leukemia inhibitory factor receptor (LIFR) mRNAs, but not of interleukin 6 receptor mRNA, was up-regulated after systemic lipopolysaccharide treatment. Because these receptors are upstream of STAT3, the present results suggest that cytokines such as LIF and/or CNTF induce SPI-3 expression via STAT3 in the pineal gland in response to inflammatory stimulus. We conclude that although the functional consequences of SPI-3 in the pineal gland during systemic inflammation are unknown, SPI-3 may have a crucial role in preventing some degenerative proteolysis induced by inflammatory stimuli. |
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Authors:
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A Takamiya; M Takeda; A Yoshida; H Kiyama |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neuroscience Volume: 113 ISSN: 0306-4522 ISO Abbreviation: Neuroscience Publication Date: 2002 |
Date Detail:
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Created Date: 2002-07-19 Completed Date: 2002-09-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7605074 Medline TA: Neuroscience Country: United States |
Other Details:
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Languages: eng Pagination: 387-94 Citation Subset: IM |
Copyright Information:
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Copyright 2002 IBRO |
Affiliation:
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Department of Anatomy, Asahikawa Medical College, 2-1 Midorigaoka Higashi Asahikawa, Hokkaido 078-8510, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute-Phase Proteins
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genetics,
metabolism* Animals DNA-Binding Proteins / metabolism Immunohistochemistry Inflammation / metabolism* Leukemia Inhibitory Factor Receptor alpha Subunit Lipopolysaccharides / pharmacology Male Pineal Gland / cytology, drug effects, metabolism* RNA, Messenger / metabolism Rats Rats, Wistar Receptor, Ciliary Neurotrophic Factor / genetics Receptors, Cytokine / genetics Receptors, OSM-LIF STAT3 Transcription Factor Serpins Trans-Activators / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Acute-Phase Proteins; 0/DNA-Binding Proteins; 0/Leukemia Inhibitory Factor Receptor alpha Subunit; 0/Lifr protein, rat; 0/Lipopolysaccharides; 0/RNA, Messenger; 0/Receptor, Ciliary Neurotrophic Factor; 0/Receptors, Cytokine; 0/Receptors, OSM-LIF; 0/STAT3 Transcription Factor; 0/Serpina3n protein, rat; 0/Serpins; 0/Stat3 protein, rat; 0/Trans-Activators |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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