Document Detail


Inflammation in subarachnoid hemorrhage and delayed deterioration associated with vasospasm: a review.
MedLine Citation:
PMID:  22890674     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Delayed deterioration associated with vasospasm (DDAV) after subarachnoid hemorrhage (SAH), (often called vasospasm) continues to be both a difficult entity to treat and a leading cause of morbidity in patients. Until recently, attention was focused on alleviating the vascular spasm. Recent evidence shows that vascular spasm may not account for all the morbidity of DDAV. There is renewed interest in looking for other potential targets for therapy. Inflammation has become a promising area of research for new treatments. This review explores the evidence that inflammation is a driver of DDAV by asking three questions: (1) If inflammation is important in the pathogenesis of the disease, what part or parts of the inflammatory response are involved? (2) When does inflammation occur in SAH? (3) In what compartment of the skull does the inflammation occur, the cerebrospinal fluid and meninges, the cerebral arteries, or the brain itself?
Authors:
J Javier Provencio
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Acta neurochirurgica. Supplement     Volume:  115     ISSN:  0065-1419     ISO Abbreviation:  Acta Neurochir. Suppl.     Publication Date:  2013  
Date Detail:
Created Date:  2012-08-14     Completed Date:  2012-12-18     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  100962752     Medline TA:  Acta Neurochir Suppl     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  233-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Humans
Inflammation / etiology*,  pathology
Subarachnoid Hemorrhage / complications*
Vasospasm, Intracranial / etiology*
Grant Support
ID/Acronym/Agency:
K08 NS051350/NS/NINDS NIH HHS; K08-NS051350/NS/NINDS NIH HHS; L30 NS066772/NS/NINDS NIH HHS
Comments/Corrections

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