Document Detail

Inflammation in subarachnoid hemorrhage and delayed deterioration associated with vasospasm: a review.
MedLine Citation:
PMID:  22890674     Owner:  NLM     Status:  MEDLINE    
Delayed deterioration associated with vasospasm (DDAV) after subarachnoid hemorrhage (SAH), (often called vasospasm) continues to be both a difficult entity to treat and a leading cause of morbidity in patients. Until recently, attention was focused on alleviating the vascular spasm. Recent evidence shows that vascular spasm may not account for all the morbidity of DDAV. There is renewed interest in looking for other potential targets for therapy. Inflammation has become a promising area of research for new treatments. This review explores the evidence that inflammation is a driver of DDAV by asking three questions: (1) If inflammation is important in the pathogenesis of the disease, what part or parts of the inflammatory response are involved? (2) When does inflammation occur in SAH? (3) In what compartment of the skull does the inflammation occur, the cerebrospinal fluid and meninges, the cerebral arteries, or the brain itself?
J Javier Provencio
Related Documents :
1614234 - Inflammation and the allergic response.
9357924 - Immunologic basis of chronic allergic diseases: clinical messages from the laboratory b...
18806704 - Use of probiotic bacteria for prevention and therapy of allergic diseases: studies in m...
15202014 - Secretory immune system in human embryonic and fetal development: joining chain and imm...
21130774 - Decision making of the p53 network: death by integration.
10201894 - Activation of cd4 t cells by somatic transgenesis induces generalized immunity of uncom...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Acta neurochirurgica. Supplement     Volume:  115     ISSN:  0065-1419     ISO Abbreviation:  Acta Neurochir. Suppl.     Publication Date:  2013  
Date Detail:
Created Date:  2012-08-14     Completed Date:  2012-12-18     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  100962752     Medline TA:  Acta Neurochir Suppl     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  233-8     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Inflammation / etiology*,  pathology
Subarachnoid Hemorrhage / complications*
Vasospasm, Intracranial / etiology*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Relevance of animal models of subarachnoid hemorrhage for examining neurobehavioral changes.
Next Document:  Attenuation of Cerebral Vasospasm Following Experimental Subarachnoid Hemorrhage by the Bronchodilat...