| Inflammation in neuroviral diseases. | |
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MedLine Citation:
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PMID: 20390431 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During any viral infection of the central nervous system (CNS), the extent and nature of neural cell alterations are dictated by the localization of virus replication and, possibly, persistence. However, one additional source of CNS damage comes from the immune response that develops following CNS viral infection. Indeed, despite of its major role in controlling virus spread in the infected CNS, the immune system is equipped with numerous molecular effectors shared with the nervous system that may greatly alter the homeostasis and function of neural cells. Proinflammatory cytokines and metalloproteases belong to this inflammatory cascade. Besides neurovirulence, the crosstalk engaged between neural and immune cells is a major factor determining the outcome of neuroviral infections. |
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Authors:
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Pascale Giraudon; Arlette Bernard |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of neural transmission (Vienna, Austria : 1996) Volume: 117 ISSN: 1435-1463 ISO Abbreviation: J Neural Transm Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-18 Completed Date: 2010-11-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9702341 Medline TA: J Neural Transm Country: Austria |
Other Details:
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Languages: eng Pagination: 899-906 Citation Subset: IM |
Affiliation:
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Faculty of Medicine Laennec, Rue Guillaume Paradin, 69372 Lyon, France. pascale.giraudon@inserm.fr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Central Nervous System*
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immunology,
pathology,
virology Central Nervous System Viral Diseases / complications*, immunology* Cytokines / metabolism Humans Inflammation / virology* |
| Chemical | |
Reg. No./Substance:
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0/Cytokines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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