| Inflammation in multiple sclerosis - sorting out the gray matter. | |
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MedLine Citation:
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PMID: 22150043 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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In this issue of the Journal, Lucchinetti and colleagues report a high prevalence of cortical gray-matter inflammation and demyelination on tissue obtained at biopsy from patients with multiple sclerosis of new onset.(1) Although several prior studies have documented demyelinating lesions in the gray matter of persons with multiple sclerosis,(2),(3) none of these investigations analyzed tissues from more than one newly diagnosed patient. The findings of the study by Lucchinetti et al. are provocative and provide definitive evidence that inflammatory disease of the gray matter commences early in the pathogenesis of some cases of multiple sclerosis. Specifically, they found cortical . . . |
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Authors:
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Peter A Calabresi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The New England journal of medicine Volume: 365 ISSN: 1533-4406 ISO Abbreviation: N. Engl. J. Med. Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0255562 Medline TA: N Engl J Med Country: United States |
Other Details:
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Languages: eng Pagination: 2231-3 Citation Subset: AIM; IM |
Affiliation:
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From the Department of Neurology, Johns Hopkins Hospital, Baltimore. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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