Document Detail

Inflammation in multiple sclerosis - sorting out the gray matter.
MedLine Citation:
PMID:  22150043     Owner:  NLM     Status:  In-Data-Review    
In this issue of the Journal, Lucchinetti and colleagues report a high prevalence of cortical gray-matter inflammation and demyelination on tissue obtained at biopsy from patients with multiple sclerosis of new onset.(1) Although several prior studies have documented demyelinating lesions in the gray matter of persons with multiple sclerosis,(2),(3) none of these investigations analyzed tissues from more than one newly diagnosed patient. The findings of the study by Lucchinetti et al. are provocative and provide definitive evidence that inflammatory disease of the gray matter commences early in the pathogenesis of some cases of multiple sclerosis. Specifically, they found cortical . . .
Peter A Calabresi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The New England journal of medicine     Volume:  365     ISSN:  1533-4406     ISO Abbreviation:  N. Engl. J. Med.     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0255562     Medline TA:  N Engl J Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2231-3     Citation Subset:  AIM; IM    
From the Department of Neurology, Johns Hopkins Hospital, Baltimore.
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