Document Detail

Inflammation in an individual joint predicts damage to that joint in psoriatic arthritis.
MedLine Citation:
PMID:  20980703     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The authors have previously reported on the relationship between activity and subsequent damage at the patient level for patients with psoriatic arthritis (PsA). The aim of this study was to identify key predictors of damage to individual joints in the hands and feet of patients with PsA, in particular those that capture previous activity.
METHODS: Data from patients followed prospectively at the University of Toronto PsA clinic between 1978 and 2006 were available for analysis. Logistic regression was used to relate the probability of a joint developing damage, within a specified time interval after the most recent clinic visit, to potential predictor variables. The predictor variables considered encompassed the history of disease activity of the joint and elsewhere, previous damage and the timing of clinical assessments.
RESULTS: 511 patients with no hand damage at clinic entry and 552 patients with no foot damage at clinic entry were included in the analysis of the hand and foot joints, respectively. The analysis of the hand and foot joints demonstrated that the activity (tenderness and/or swelling) history of the specific joint is associated with subsequent damage. For the joints of the feet, activity observations elsewhere in the same foot, and in particular the same toe, were also shown to be associated with subsequent damage.
CONCLUSIONS: Both joint tenderness and swelling are important predictors of joint damage in PsA.
Lynne Cresswell; Vinod Chandran; Vernon T Farewell; Dafna D Gladman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-10-27
Journal Detail:
Title:  Annals of the rheumatic diseases     Volume:  70     ISSN:  1468-2060     ISO Abbreviation:  Ann. Rheum. Dis.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-14     Completed Date:  2011-02-17     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  0372355     Medline TA:  Ann Rheum Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  305-8     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Arthritis, Psoriatic / pathology*
Disease Progression
Epidemiologic Methods
Foot Joints / pathology*
Hand Joints / pathology*
Middle Aged
Young Adult
Grant Support
MC_U105261167//Medical Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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