| Inflammation, high-density lipoprotein and cardiovascular dysfunction. | |
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MedLine Citation:
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PMID: 21326098 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: This review describes the evidence that supports the hypothesis that high-density lipoprotein (HDL) is atheroprotective due to its antiinflammatory effects and benefits on vascular health. RECENT FINDINGS: Recent investigations have shown that HDL may inhibit atherosclerosis by promoting healthy endothelial function and by limiting or inhibiting the activation of macrophage and other immune cells. Receptors for HDL clearly regulate immune system function as well as cellular stress. Recent studies also suggest that participation of HDL in the process of reverse cholesterol transport may inhibit growth factor and cytokine receptor signaling by depleting cholesterol from lipid rafts. However, inflammation can also be associated with circulating dysfunctional HDL, which often possesses both prooxidative and proinflammatory properties. SUMMARY: These studies suggest that HDL-based therapeutics have potential in treating both acute and chronic conditions associated with inflammation. These studies also reveal several other pathways that may be targeted for therapeutic drug development. |
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Authors:
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Michael J Haas; Arshag D Mooradian |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Current opinion in infectious diseases Volume: 24 ISSN: 1473-6527 ISO Abbreviation: Curr. Opin. Infect. Dis. Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-04-22 Completed Date: 2011-08-02 Revised Date: 2012-01-31 |
Medline Journal Info:
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Nlm Unique ID: 8809878 Medline TA: Curr Opin Infect Dis Country: United States |
Other Details:
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Languages: eng Pagination: 265-72 Citation Subset: IM |
Affiliation:
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Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Florida-Jacksonville College of Medicine, Jacksonville, Florida, USA. michael.haas@jax.ufl.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Inflammatory Agents
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metabolism* Cardiovascular Diseases / prevention & control* Coronary Artery Disease / prevention & control* Humans Inflammation / prevention & control* Lipoproteins, HDL / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Lipoproteins, HDL |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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