Document Detail


Inflammation and coronary angiography in asymptomatic type 2 diabetic subjects.
MedLine Citation:
PMID:  17454845     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Coronary artery disease (CAD) is prevalent in patients with type 2 diabetes mellitus (T2DM) and because it is often asymptomatic and extensive in comparison with CAD in subjects without diabetes, it represents a diagnostic challenge. The objective of the study was to investigate the prevalence of CAD in asymptomatic T2DM patients utilizing angiography and to investigate its association with cardiovascular (CV) risk factors, the metabolic syndrome and markers of inflammation. MATERIAL AND METHODS: Eighty-two patients with T2DM without symptoms of CAD, and with >or=1 CV risk factor (hypertension, dyslipidaemia, premature familial CAD, smoking or microalbuminuria) underwent a diagnostic stress test and coronary angiography irrespective of stress test results. Stenosis detected in the main coronary arteries >or=50% of lumen diameter was categorized as one-, two- or three-vessel disease. Inflammatory markers were analysed in fasting samples. RESULTS: Fifteen men and two women had significant CAD (21%) (1-vessel disease, n=10; 2- or 3-vessel disease, n=7). Patients with 2- or 3-vessel disease were significantly older and had a longer duration of diabetes, but the prevalence of other traditional CV risk factors or the metabolic syndrome was similar among those with 1-vessel and those with 2- or 3-vessel disease. Sensitivity for CAD of the stress test was low (0.35). The mean level of the pro-inflammatory marker interleukin-6 was elevated in patients with 2- to 3-vessel CAD as compared to patients with no or 1-vessel CAD (p<0.05). CONCLUSIONS: Significant CAD was found in 21% of asymptomatic patients with T2DM with >or=1 CV risk factor. Inflammatory markers may be helpful in identifying patients that are likely to have significant CAD, but larger studies are warranted.
Authors:
O E Johansen; K I Birkeland; E Orvik; Ø Flesland; R Wergeland; T Ueland; C Smith; K Endresen; P Aukrust; L Gullestad
Related Documents :
3795395 - Dipyridamole thallium 201 scintigraphy to detect coronary artery disease before abdomin...
10551265 - Activation of monocytes, t-lymphocytes and plasma inflammatory markers in angina patients.
16490815 - Correlates and long-term outcomes of angiographically proven stent thrombosis with siro...
6734645 - Prevalence of vasospastic ischaemia induced by the cold pressor test or hyperventilatio...
22850495 - Spinal cord stimulation for treatment of patients in the minimally conscious state.
868805 - An evaluation of a kinetic acid phosphatase method.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of clinical and laboratory investigation     Volume:  67     ISSN:  0036-5513     ISO Abbreviation:  Scand. J. Clin. Lab. Invest.     Publication Date:  2007  
Date Detail:
Created Date:  2007-04-24     Completed Date:  2007-08-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0404375     Medline TA:  Scand J Clin Lab Invest     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  306-16     Citation Subset:  IM    
Affiliation:
Medical Department, Asker and Baerum Hospital, Rud, Norway. odd.erik.johansen@broadpark.no
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age Distribution
Aged
Comorbidity
Coronary Angiography
Coronary Artery Disease / epidemiology*,  physiopathology,  radiography*
Coronary Stenosis / epidemiology,  radiography
Diabetes Complications / epidemiology*,  physiopathology,  radiography*
Diabetes Mellitus, Type 2 / epidemiology*
Exercise Test
Female
Humans
Inflammation / blood,  epidemiology*
Interleukin-6 / blood
Male
Middle Aged
Norway / epidemiology
Prevalence
Risk Factors
Sex Distribution
Chemical
Reg. No./Substance:
0/Interleukin-6

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Applicability of estimated glomerular filtration rate in stratifying chronic kidney disease.
Next Document:  Serum ionized magnesium and calcium levels in adult patients with seizures.