Document Detail


Inflammation and conjugated linoleic acid: mechanisms of action and implications for human health.
MedLine Citation:
PMID:  16440602     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Data from a number of studies and trials have shown that different conjugated linoleic acids (CLA's) may produce beneficial effects on cancer, atherosclerosis, hypertension, diabetes and changes in body composition. Despite the increasing knowledge about CLA's implications on health, the mechanism of action of these fatty acids is not completely understood. Moreover, human studies indicate that some of these beneficial effects are considerably less evident than anticipated from mice studies, while the efficacy and safety of dietary supplements containing CLA have been questioned in some intervention trials. Recently, it has been suggested that the anti-carcinogenic and anti-atherosclerosis effects of CLA's stem from its anti-inflammatory properties. Because inflammatory responses are associated with the pathophysiology of many diseases, including obesity and the metabolic syndrome, the investigation in this area is of growing interest in recent years.
Authors:
M A Zulet; A Marti; M D Parra; J A Martínez
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of physiology and biochemistry     Volume:  61     ISSN:  1138-7548     ISO Abbreviation:  J. Physiol. Biochem.     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2006-01-30     Completed Date:  2006-03-02     Revised Date:  2006-06-09    
Medline Journal Info:
Nlm Unique ID:  9812509     Medline TA:  J Physiol Biochem     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  483-94     Citation Subset:  IM    
Affiliation:
Departamento de Fisiología y Nutrición, Facultad de Farmacia, Universidad de Navarra, Pamplona, Spain.
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MeSH Terms
Descriptor/Qualifier:
Anti-Inflammatory Agents / pharmacology,  therapeutic use*
Humans
Inflammation / drug therapy*
Linoleic Acid / pharmacology,  therapeutic use*
Metabolic Syndrome X
Obesity
Oxidative Stress
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 2197-37-7/Linoleic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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