| Inflammation of the brain in Alzheimer's disease: implications for therapy. | |
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MedLine Citation:
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PMID: 10204568 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We briefly describe the similarities and differences between a systemic and a local immune reaction and review the evidence that the latter occurs in Alzheimer's disease (AD) brains. The evidence comes mainly from studies on the complement system, microglia, and cytokines, all of which are important actors in the inflammatory process. The evidence is now overwhelming that the complement proteins and many of the mediators of inflammation are produced locally by brain cells. We will mention briefly the many epidemiological studies indicating that the use of anti-inflammatory drugs reduces the incidence and slows the progress of AD. Mention will also be made of some recent work on animal models of possible relevance to AD and inflammation. |
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Authors:
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P L McGeer; E G McGeer |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Journal of leukocyte biology Volume: 65 ISSN: 0741-5400 ISO Abbreviation: J. Leukoc. Biol. Publication Date: 1999 Apr |
Date Detail:
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Created Date: 1999-04-29 Completed Date: 1999-04-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8405628 Medline TA: J Leukoc Biol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 409-15 Citation Subset: IM |
Affiliation:
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Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, Canada. mcgeerpl@unixg.ubc.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alzheimer Disease
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complications,
immunology*,
therapy* Animals Brain / pathology* Humans Immunotherapy / methods* Inflammation / etiology, immunology, therapy |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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