Document Detail


Inflammation, autophagy, and obesity: common features in the pathogenesis of pancreatitis and pancreatic cancer.
MedLine Citation:
PMID:  23622129     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Inflammation and autophagy are cellular defense mechanisms. When these processes are deregulated (deficient or overactivated) they produce pathologic effects, such as oxidative stress, metabolic impairments, and cell death. Unresolved inflammation and disrupted regulation of autophagy are common features of pancreatitis and pancreatic cancer. Furthermore, obesity, a risk factor for pancreatitis and pancreatic cancer, promotes inflammation and inhibits or deregulates autophagy, creating an environment that facilitates the induction and progression of pancreatic diseases. However, little is known about how inflammation, autophagy, and obesity interact to promote exocrine pancreatic disorders. We review the roles of inflammation and autophagy, and their deregulation by obesity, in pancreatic diseases. We discuss the connections among disordered pathways and important areas for future research.
Authors:
Ilya Gukovsky; Ning Li; Jelena Todoric; Anna Gukovskaya; Michael Karin
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Gastroenterology     Volume:  144     ISSN:  1528-0012     ISO Abbreviation:  Gastroenterology     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-04-29     Completed Date:  2013-06-20     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1199-209.e4     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2013 AGA Institute. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Autophagy*
Humans
Inflammation / complications*,  immunology,  metabolism,  pathology
Inflammation Mediators / metabolism
Obesity / complications*,  immunology,  metabolism,  pathology
Pancreas / immunology,  metabolism,  pathology*
Pancreatic Neoplasms / etiology*,  immunology,  metabolism,  pathology
Pancreatitis / etiology*,  immunology,  metabolism,  pathology
Risk Factors
Signal Transduction
Grant Support
ID/Acronym/Agency:
AA19730/AA/NIAAA NIH HHS; AI043477/AI/NIAID NIH HHS; CA163798/CA/NCI NIH HHS; DK59936/DK/NIDDK NIH HHS; P01 CA163200/CA/NCI NIH HHS; P01 CA163200/CA/NCI NIH HHS; P50 AA011999/AA/NIAAA NIH HHS; P50 AA011999/AA/NIAAA NIH HHS; R01 AA019730/AA/NIAAA NIH HHS; R01 AI043477/AI/NIAID NIH HHS; R01 CA163798/CA/NCI NIH HHS; R01 DK059936/DK/NIDDK NIH HHS; R03 CA167120/CA/NCI NIH HHS; R03CA167120/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Inflammation Mediators
Comments/Corrections

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