Document Detail

Inflammation and atherosclerosis. Atherosclerotic lesions in Takayasu arteritis.
MedLine Citation:
PMID:  10865826     Owner:  NLM     Status:  MEDLINE    
Takayasu arteritis is a chronic vasculitis, mainly involving the aorta and its main branches as well as the coronary and pulmonary arteries, causing stenosis and/or obstruction due to thrombus formation or dilatation due to aneurysmal formation and/or rupture of the involved arteries. These characteristic anomalies resulted from ischemia of retinal arteries due to the obstruction of cervical vessels. In Western countries this disease is also known as "pulseless disease," because the pulse is frequently absent due to the obstruction of subclavian or branchial arteries. The pathogenesis of this morbid condition is still unknown. Epidemiologically, it is found mostly in female patients and is more prevalent in Asian and Latin American countries. Affected areas consist of a mixture of both active, productive inflammatory lesions, and old fibrous lesions. Autoimmune processes stimulated by viral infection and other unknown causative factors may play an important role under these pathophysiological conditions because HLA analysis revealed a statistically significant high frequency of haplotype A24-B52-DR2 in these patients in Japan. Documentation of atherosclerotic complications in young female patients with Takayasu arteritis who are generally free from traditional atherosclerosis risk factors may be clinical evidence that inflammation is indeed an important risk factor in atherogenesis.
F Numano; Y Kishi; A Tanaka; M Ohkawara; T Kakuta; Y Kobayashi
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  902     ISSN:  0077-8923     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-07-11     Completed Date:  2000-07-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  65-76     Citation Subset:  IM    
Third Department of Internal Medicine, Tokyo Medical and Dental University, Japan.
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MeSH Terms
Arteries / pathology*
Arteriosclerosis / pathology*
Asia / epidemiology
Inflammation / physiopathology
Latin America / epidemiology
Takayasu Arteritis / epidemiology,  pathology*,  physiopathology*

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