Document Detail


Inflammation as a risk factor for carotid intimal-medial thickening, a measure of subclinical atherosclerosis in haemodialysis patients: the role of chlamydia and cytomegalovirus infection.
MedLine Citation:
PMID:  17295657     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Atherosclerotic vascular disease is the most frequent complication seen in haemodialysis (HD) patients. Evidence suggests that inflammation may play a role in the pathogenesis and progression of atherosclerosis. Our aim was to evaluate the causative role of inflammation in atherosclerosis among HD patients. METHODS: Intima-media thickness (IMT) in carotid arteries was determined in 54 HD patients and 52 controls. Plasma levels of lipids, glucose, albumin and several acute phase proteins, and immunoglobulin G titres against chlamydia and cytomegalovirus were measured in all subjects. RESULTS: Mean carotid IMT was significantly greater in HD patients than in controls (0.75 mm vs 0.56 mm, P < 0.005). While plasma levels of C-reactive protein (CRP), serum amyloid A (SAA), lipoprotein (a) Lp(a), fibrinogen and ferritin were higher in HD patients, albumin levels were lower. In HD patients, carotid IMT was correlated positively with CRP (R = 0.29, P = 0.019), SAA (R = 0.69, P < 0.001), Lp(a) (R = 0.42, P = 0.001), fibrinogen (R = 0.57, P < 0.001) and chlamydia pneumonia immunoglobulin G titres (R = 0.50, P < 0.001), and negatively with albumin levels (R = -0.33, P = 0.02); there was no relationship between carotid IMT and hypertension, plasma lipid levels and cytomegalovirus. In multivariate regression analysis, these variables still showed a significant relationship with IMT (R(2) = 0.694 and P < 0.001). CONCLUSION: We conclude that atherosclerotic changes are more common in HD patients than in controls, and that inflammatory processes may play a role in the pathogenesis of atherosclerosis.
Authors:
Hakan Buyukhatipoglu; Ozlem Tiryaki; Kadir Tahta; Celalettin Usalan
Related Documents :
11990807 - Reversible dementia in patients with chronic subdural hematomas.
21264797 - Increased gallium-68 dotatoc uptake in normal thyroid glands.
17643057 - Effect of n-acetylcysteine on endothelial dysfunction in dialysis patients.
8616177 - Treatment modality selection in 150 consecutive patients starting esrd therapy.
11278147 - Cytokine profiles in drug-naive schizophrenic patients.
2229837 - Immunotherapy abrogates the generation of eosinophil and neutrophil chemotactic activit...
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Nephrology (Carlton, Vic.)     Volume:  12     ISSN:  1320-5358     ISO Abbreviation:  Nephrology (Carlton)     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-02-13     Completed Date:  2007-04-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9615568     Medline TA:  Nephrology (Carlton)     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  25-32     Citation Subset:  IM    
Affiliation:
Division of Nephrology, Faculty of Medicine, Gaziantep University, Turkey. buyukhatip@yahoo.com
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Acute-Phase Proteins / analysis
Adult
Amyloid / blood
Atherosclerosis / microbiology*,  pathology*,  ultrasonography
C-Reactive Protein / analysis
Carotid Arteries / pathology*,  ultrasonography
Case-Control Studies
Chlamydia Infections / complications*
Chlamydophila pneumoniae
Cytomegalovirus
Cytomegalovirus Infections / complications*
Female
Ferritins / blood
Fibrinogen / analysis
Humans
Immunoglobulin G / blood
Inflammation
Lipoprotein(a) / blood
Male
Middle Aged
Renal Dialysis*
Risk Factors
Tunica Intima / pathology*,  ultrasonography
Tunica Media / pathology*,  ultrasonography
Chemical
Reg. No./Substance:
0/Acute-Phase Proteins; 0/Amyloid; 0/Immunoglobulin G; 0/Lipoprotein(a); 9001-32-5/Fibrinogen; 9007-41-4/C-Reactive Protein; 9007-73-2/Ferritins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Impairments of the biological properties of serum albumin in patients on haemodialysis.
Next Document:  Carbamazepine poisoning managed with haemodialysis and haemoperfusion in three adolescents.