Document Detail

Inflammation as a risk factor for carotid intimal-medial thickening, a measure of subclinical atherosclerosis in haemodialysis patients: the role of chlamydia and cytomegalovirus infection.
MedLine Citation:
PMID:  17295657     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Atherosclerotic vascular disease is the most frequent complication seen in haemodialysis (HD) patients. Evidence suggests that inflammation may play a role in the pathogenesis and progression of atherosclerosis. Our aim was to evaluate the causative role of inflammation in atherosclerosis among HD patients. METHODS: Intima-media thickness (IMT) in carotid arteries was determined in 54 HD patients and 52 controls. Plasma levels of lipids, glucose, albumin and several acute phase proteins, and immunoglobulin G titres against chlamydia and cytomegalovirus were measured in all subjects. RESULTS: Mean carotid IMT was significantly greater in HD patients than in controls (0.75 mm vs 0.56 mm, P < 0.005). While plasma levels of C-reactive protein (CRP), serum amyloid A (SAA), lipoprotein (a) Lp(a), fibrinogen and ferritin were higher in HD patients, albumin levels were lower. In HD patients, carotid IMT was correlated positively with CRP (R = 0.29, P = 0.019), SAA (R = 0.69, P < 0.001), Lp(a) (R = 0.42, P = 0.001), fibrinogen (R = 0.57, P < 0.001) and chlamydia pneumonia immunoglobulin G titres (R = 0.50, P < 0.001), and negatively with albumin levels (R = -0.33, P = 0.02); there was no relationship between carotid IMT and hypertension, plasma lipid levels and cytomegalovirus. In multivariate regression analysis, these variables still showed a significant relationship with IMT (R(2) = 0.694 and P < 0.001). CONCLUSION: We conclude that atherosclerotic changes are more common in HD patients than in controls, and that inflammatory processes may play a role in the pathogenesis of atherosclerosis.
Hakan Buyukhatipoglu; Ozlem Tiryaki; Kadir Tahta; Celalettin Usalan
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Nephrology (Carlton, Vic.)     Volume:  12     ISSN:  1320-5358     ISO Abbreviation:  Nephrology (Carlton)     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-02-13     Completed Date:  2007-04-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9615568     Medline TA:  Nephrology (Carlton)     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  25-32     Citation Subset:  IM    
Division of Nephrology, Faculty of Medicine, Gaziantep University, Turkey.
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MeSH Terms
Acute-Phase Proteins / analysis
Amyloid / blood
Atherosclerosis / microbiology*,  pathology*,  ultrasonography
C-Reactive Protein / analysis
Carotid Arteries / pathology*,  ultrasonography
Case-Control Studies
Chlamydia Infections / complications*
Chlamydophila pneumoniae
Cytomegalovirus Infections / complications*
Ferritins / blood
Fibrinogen / analysis
Immunoglobulin G / blood
Lipoprotein(a) / blood
Middle Aged
Renal Dialysis*
Risk Factors
Tunica Intima / pathology*,  ultrasonography
Tunica Media / pathology*,  ultrasonography
Reg. No./Substance:
0/Acute-Phase Proteins; 0/Amyloid; 0/Immunoglobulin G; 0/Lipoprotein(a); 9001-32-5/Fibrinogen; 9007-41-4/C-Reactive Protein; 9007-73-2/Ferritins

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