| Minireview: Inflammation and obesity pathogenesis: the hypothalamus heats up. | |
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MedLine Citation:
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PMID: 20573720 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Obesity induced by high-fat (HF) feeding is associated with low-grade inflammation in peripheral tissues that predisposes to insulin resistance. Recent evidence suggests the occurrence of a similar process in the hypothalamus, which favors weight gain through impairment of leptin and insulin signaling. In addition to its implications for obesity pathogenesis, this hypothesis suggests that centrally targeted antiinflammatory therapies may prove effective in prevention and treatment of this disorder. This article highlights molecular and cellular mechanisms by which hypothalamic inflammation predisposes to diet-induced obesity. |
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Authors:
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Joshua P Thaler; Michael W Schwartz |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2010-06-23 |
Journal Detail:
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Title: Endocrinology Volume: 151 ISSN: 1945-7170 ISO Abbreviation: Endocrinology Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-25 Completed Date: 2010-10-04 Revised Date: 2013-03-28 |
Medline Journal Info:
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Nlm Unique ID: 0375040 Medline TA: Endocrinology Country: United States |
Other Details:
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Languages: eng Pagination: 4109-15 Citation Subset: AIM; IM |
Affiliation:
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Division of Metabolism, Endocrinology, and Nutrition, University of Washington, Seattle, Washington 98109, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Glucose Intolerance / metabolism, physiopathology Humans Hypothalamus / physiopathology* Inflammation / metabolism, physiopathology* Insulin Resistance* Leptin / metabolism Models, Biological Obesity / metabolism, physiopathology* Weight Gain / physiology |
| Grant Support | |
ID/Acronym/Agency:
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DK007247/DK/NIDDK NIH HHS; DK052989/DK/NIDDK NIH HHS; DK068384/DK/NIDDK NIH HHS; DK083042/DK/NIDDK NIH HHS; R01 DK052989-14/DK/NIDDK NIH HHS; R01 DK090320-02/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Leptin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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