| Inflammation of the Fetal Ovine Skin Following in utero Exposure to Ureaplasma parvum. | |
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MedLine Citation:
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PMID: 22031190 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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There is increasing evidence linking in utero infection and inflammation to preterm birth. Many commensal urogenital tract microorganisms, including the Mycoplasmas and Ureaplasmas, are commonly detected in association with preterm birth. Using an ovine model of sterile fetal inflammation, we demonstrated previously that the fetal skin generates a robust inflammatory response following in utero exposure to lipopolysaccharides from Escherichia coli. The fetal skin's response to colonization of the amniotic fluid by viable microorganisms remains unstudied. We hypothesised that in utero infection with Ureaplasma parvum serovar 3 would induce a proinflammatory response in the fetal skin. We found that (1) cultured fetal keratinocytes (the primary cellular constituent of the epidermis) respond to U. parvum exposure in vitro by increasing the expression of the chemotactant monocyte chemoattractant protein 1 (MCP-1) but not interleukin 1β (IL-1β), IL-6, IL-8, or tumor necrosis factor-α (TNF-α); (2) the fetal skin's response to 7 days of U. parvum exposure is characterized by elevated expression of MCP-1, TNF-α, and IL-10; and (3) the magnitude of inflammatory cytokine/chemokine expression in the fetal skin is dependent on the duration of U parvum exposure. These novel findings provide further support for the role of the fetal skin in the development of fetal inflammation and the preterm birth that may follow. |
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Authors:
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Matthew W Kemp; Masatoshi Saito; Suhas G Kallapur; Alan H Jobe; Jeffrey A Keelan; Shaofu Li; Boris Kramer; Li Zhang; Christine Knox; Nobuo Yaegashi; John P Newnham |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Reproductive sciences (Thousand Oaks, Calif.) Volume: 18 ISSN: 1933-7205 ISO Abbreviation: Reprod Sci Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-10-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101291249 Medline TA: Reprod Sci Country: United States |
Other Details:
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Languages: eng Pagination: 1128-37 Citation Subset: IM |
Affiliation:
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1School of Women's and Infants' Health, The University of Western Australia, Perth, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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