| Is inflammation a common retinal-renal-nerve pathogenic link in diabetes? | |
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MedLine Citation:
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PMID: 20594163 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The global diabetes burden is predicted to rise to 380 million by 2025 and would present itself as a major health challenge. However, both Type 1 and Type 2 diabetes increase the risk of developing micro-vascular complications and macro-vascular complications which in turn will have a devastating impact on quality of life of the patients and challenge health services Worldwide. The micro-vascular complications that affect small blood vessels are the leading cause of blindness (diabetic retinopathy) in the people of the working-age, end-stage renal disease (diabetic nephropathy) the most common cause of kidney failure today, and foot amputation (diabetic neuropathy) in patients with Type 1 and Type 2 diabetes. It is accepted that hyperglycemia is a major causative factor for the development of these complications, there is also growing evidence for the role of inflammation. Here we discuss low-grade inflammation as a common retinal-renal-nerve pathogenic link in patients with Type 1 and Type 2 diabetes. This review summarizes evidence showing a link between circulating and locally produced inflammatory biomarkers, such as cell adhesion molecules (vascular adhesion cell molecule-1, VCAM-1; intracellular adhesion molecule-1, ICAM-1), pro-inflammatory cytokines (interleukin-6, IL-6; tumour necrosis factor-alpha, TNF-α; C-reactive protein, CRP) with the development and progression of diabetic micro-vascular complications. |
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Authors:
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Kirti Kaul; Andrea Hodgkinson; J M Tarr; Eva M Kohner; Rakesh Chibber |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Current diabetes reviews Volume: 6 ISSN: 1875-6417 ISO Abbreviation: Curr Diabetes Rev Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-20 Completed Date: 2011-01-12 Revised Date: 2011-07-08 |
Medline Journal Info:
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Nlm Unique ID: 101253260 Medline TA: Curr Diabetes Rev Country: United Arab Emirates |
Other Details:
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Languages: eng Pagination: 294-303 Citation Subset: IM |
Affiliation:
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Institute of Biomedical and Clinical Science, Peninsula College of Medicine and Dentistry, University of Exeter & Plymouth, St Luke's Campus, Exeter EX1 2LU, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Markers / analysis, blood, metabolism Diabetic Nephropathies / blood, etiology, metabolism, pathology Diabetic Neuropathies / blood, etiology*, metabolism, pathology Diabetic Retinopathy / blood, etiology, metabolism, pathology Humans Inflammation / blood, complications*, metabolism, pathology Kidney / innervation*, metabolism, pathology Models, Biological Nephritis / blood, complications, metabolism, pathology Retina / immunology, metabolism, pathology Retinal Neurons / metabolism, pathology* Retinitis / blood, complications, metabolism, pathology |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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