| Inflammasomes in health and disease. | |
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MedLine Citation:
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PMID: 22258606 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Inflammasomes are a group of protein complexes built around several proteins, including NLRP3, NLRC4, AIM2 and NLRP6. Recognition of a diverse range of microbial, stress and damage signals by inflammasomes results in direct activation of caspase-1, which subsequently induces secretion of potent pro-inflammatory cytokines and a form of cell death called pyroptosis. Inflammasome-mediated processes are important during microbial infections and also in regulating both metabolic processes and mucosal immune responses. We review the functions of the different inflammasome complexes and discuss how aberrations in them are implicated in the pathogenesis of human diseases. |
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Authors:
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Till Strowig; Jorge Henao-Mejia; Eran Elinav; Richard Flavell |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2012-01-18 |
Journal Detail:
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Title: Nature Volume: 481 ISSN: 1476-4687 ISO Abbreviation: Nature Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-01-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0410462 Medline TA: Nature Country: England |
Other Details:
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Languages: eng Pagination: 278-86 Citation Subset: IM |
Affiliation:
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Department of Immunobiology, Yale University, Connecticut 06520, USA. |
Export Citation:
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Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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//Howard Hughes Medical Institute |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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