Document Detail


Inflammasomes in Wound Healing and Fibrosis.
MedLine Citation:
PMID:  23023641     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Inflammasome signaling and downstream cytokine responses mediated by the inflammasome have been found to play an important role not only in wound healing but also in fibrosis. The inflammasome regulates the secretion of IL-1βand IL-18 cytokines are both are critical for the repair of damaged tissue and they play a role in fibrosis. However, what dictates the fine balance between normal wound healing versus fibrosis is yet to be fully elucidated. Further investigations into the role of the inflammasomes in these pathologies will be important for the discovery of novel therapeutics that can abrogate fibrosis or promote wound healing in chronic disease. Copyright © 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Authors:
Carol M Artlett
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-1
Journal Detail:
Title:  The Journal of pathology     Volume:  -     ISSN:  1096-9896     ISO Abbreviation:  J. Pathol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0204634     Medline TA:  J Pathol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Affiliation:
Associate Professor of Microbiology and Immunology Drexel University College of Medicine 2900 Queen Lane, Philadelphia PA 19129. carol.artlett@drexelmed.edu.
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