| Inflammasomes and anti-viral immunity. | |
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MedLine Citation:
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PMID: 20665097 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Type I Interferons are the hallmark cytokines deployed during infection to combat invading viruses. However, inflammatory cytokines such as Interleukin (IL)-1beta and IL-18 also play important roles in anti-viral defenses. The activity of IL-1beta and IL18 are regulated at the level of expression, processing, and secretion. Several classes of innate immune receptors control the expression of these cytokines, which must then be proteolytically processed via caspase-1. In this review, we provide an overview of how caspase-1-activating inflammasomes participate during viral infections and their role in regulating anti-viral immunity. |
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Authors:
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Vijay A K Rathinam; Katherine A Fitzgerald |
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Publication Detail:
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Type: Journal Article Date: 2010-07-28 |
Journal Detail:
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Title: Journal of clinical immunology Volume: 30 ISSN: 1573-2592 ISO Abbreviation: J. Clin. Immunol. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-09 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8102137 Medline TA: J Clin Immunol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 632-7 Citation Subset: IM |
Affiliation:
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Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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