Document Detail

The Inflammasome in Myocardial Injury and Cardiac Remodeling.
MedLine Citation:
PMID:  25330141     Owner:  NLM     Status:  Publisher    
Significance. An inflammatory response follows an injury of any nature, and while such response is an attempt to promote healing, it may itself result in further injury. Recent Advances. The inflammasome is a macromolecular structure recently recognized as a central mediator in the acute inflammatory response. The inflammasome senses the injury and it amplifies the response by leading to the release of powerful pro-inflammatory cytokines, Interleukin-1β (IL-1β) and IL-18. Critical Issues. The activation of the inflammasome in the heart during ischemic and non-ischemic injury represents an exaggerated response to sterile injury and promotes adverse cardiac remodeling and failure. Future Directions. Pilot clinical trials have explored blockade of the inflammasome-derived IL-1β and have shown beneficial effects on cardiac function. Additional clinical studies testing this approach are warranted. Moreover, specific inflammasome inhibitors that are ready for clinical use are currently lacking.
Stefano Toldo; Eleonora Mezzaroma; Adolfo Gabriele Mauro; Fadi N Salloum; Benjamin Wallace Van Tassell; Antonio Stoldo2 Vcu Edu Abbate
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-10-20
Journal Detail:
Title:  Antioxidants & redox signaling     Volume:  -     ISSN:  1557-7716     ISO Abbreviation:  Antioxid. Redox Signal.     Publication Date:  2014 Oct 
Date Detail:
Created Date:  2014-10-20     Completed Date:  -     Revised Date:  2014-10-21    
Medline Journal Info:
Nlm Unique ID:  100888899     Medline TA:  Antioxid Redox Signal     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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