Document Detail


The Inflammasome in Myocardial Injury and Cardiac Remodeling.
MedLine Citation:
PMID:  25330141     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Significance. An inflammatory response follows an injury of any nature, and while such response is an attempt to promote healing, it may itself result in further injury. Recent Advances. The inflammasome is a macromolecular structure recently recognized as a central mediator in the acute inflammatory response. The inflammasome senses the injury and it amplifies the response by leading to the release of powerful pro-inflammatory cytokines, Interleukin-1β (IL-1β) and IL-18. Critical Issues. The activation of the inflammasome in the heart during ischemic and non-ischemic injury represents an exaggerated response to sterile injury and promotes adverse cardiac remodeling and failure. Future Directions. Pilot clinical trials have explored blockade of the inflammasome-derived IL-1β and have shown beneficial effects on cardiac function. Additional clinical studies testing this approach are warranted. Moreover, specific inflammasome inhibitors that are ready for clinical use are currently lacking.
Authors:
Stefano Toldo; Eleonora Mezzaroma; Adolfo Gabriele Mauro; Fadi N Salloum; Benjamin Wallace Van Tassell; Antonio Stoldo2 Vcu Edu Abbate
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-10-20
Journal Detail:
Title:  Antioxidants & redox signaling     Volume:  -     ISSN:  1557-7716     ISO Abbreviation:  Antioxid. Redox Signal.     Publication Date:  2014 Oct 
Date Detail:
Created Date:  2014-10-20     Completed Date:  -     Revised Date:  2014-10-21    
Medline Journal Info:
Nlm Unique ID:  100888899     Medline TA:  Antioxid Redox Signal     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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