| The inflammasome regulatory pathway and infections: Role in pathophysiology and clinical implications. | |
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MedLine Citation:
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PMID: 20950647 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The innate immune system serves to generate immediate host defenses against pathogens. Advance in the mechanism of innate immunity has provided new insights into host-pathogen microbial interactions. The cytosolic multi-protein complex called the inflammasome, which regulates the caspase-1 dependent processing of inflammatory cytokines IL-1β and IL-18, is critical for the innate defense against pathogens. We summarize the current knowledge regarding the regulatory functions of the inflammasome in the pathogenesis of infections by various microbes (e.g., bacteria, fungi, viruses, and protozoa), and discuss its potential application in a clinical setting. Understanding of the unique role of the inflammasome signaling pathway in initiating and regulating inflammation is pivotal for the development of innovative approaches to optimize management of these infections. |
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Authors:
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Ryosuke Osawa; Kristi L Williams; Nina Singh |
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Publication Detail:
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Type: Journal Article Date: 2010-10-13 |
Journal Detail:
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Title: The Journal of infection Volume: 62 ISSN: 1532-2742 ISO Abbreviation: J. Infect. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7908424 Medline TA: J Infect Country: England |
Other Details:
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Languages: eng Pagination: 119-29 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 The British Infection Association. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Medicine, VA Pittsburgh Healthcare System and University of Pittsburgh, Pittsburgh, PA, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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