| Inflammasome - IL-1 - Th17 response in allergic lung inflammation. | |
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MedLine Citation:
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PMID: 22147847 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Allergic asthma has increased dramatically in prevalence and severity over the last three decades. Both clinical and experimental data support an important role of Th2 cell response in the allergic response. Recent investigations revealed that airway exposure to allergen in sensitized individuals causes the release of ATP and uric acid activating the NLRP3 inflammasome complex and caspase-1 cleaving pro-IL-1β to mature IL-1β. The production of pro-IL-1β requires a TLR4 signal which is provided by the allergen. IL-1β creates a pro-inflammatory milieu with the production of IL-6 and chemokines which mobilize neutrophils and enhance Th17 cell differentiation in the lung. Here, we review our results showing that NLRP3 inflammasome activation is required to develop allergic airway inflammation in mice and that IL-17 and IL-22 production by Th17 plays a critical role in established asthma. Therefore, inflammasome activation leading to IL-1β production contributes to the control of allergic asthma by enhancing Th17 cell differentiation. |
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Authors:
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Anne-Gaelle Besnard; Dieudonnée Togbe; Isabelle Couillin; Zoming Tan; Song-Guo Zheng; François Erard; Marc Le Bert; Valérie Quesniaux; Bernhard Ryffel |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-6 |
Journal Detail:
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Title: Journal of molecular cell biology Volume: - ISSN: 1759-4685 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101503669 Medline TA: J Mol Cell Biol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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University of Orleans and Molecular Immunology and Embryology, CNRS UMR6218, Orleans, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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