Document Detail


Inflammaging and Proteases in Abdominal Aortic Aneurysm.
MedLine Citation:
PMID:  22724479     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abdominal aortic aneurysm (AAA) is an age-related disease resulting in aortic wall weakening and dilatation which may progress to the fatal point of abrupt aortic wall rupture. Chronic inflammation is a driving force in the pathogenesis of AAA and extracellular matrix (ECM) proteases are considered central to aortic wall degradation. Considerable effort is dedicated to identifying the proteases responsible as well as the mechanism by which these proteases contribute to disease progression. As such, they are considered important molecular targets for pharmacological intervention. Along with smoking, male gender and family history, aging is a major risk factor for AAA. Examination of age-related changes of the immune system reveals an interwoven relationship between the processes of aging and chronic inflammation, collectively predisposing to AAA development. The present review explores current evidence as to the role of specific ECM proteases in AAA pathogenesis. The contribution of the aging process to disease pathogenesis is also explored to provide the relevant context and highlight key molecular pathways that should be considered while attempting to develop effective treatment approaches.
Authors:
Alon Hendel; Lisa S Ang; David J Granville
Related Documents :
22739329 - Off-ice fitness of elite female ice hockey players by team success, age, and player pos...
19300309 - A population-based study of age inequalities in access to palliative care among cancer ...
22419449 - Normative data and longitudinal invariance of the life engagement test (let) in a commu...
8661599 - Reduction mammoplasty by the central pedicle, avoiding a vertical scar.
8151719 - Race: an explanation of patient compliance--fact or fiction?
22984599 - Bag3-induced autophagy is associated with degradation of jcv oncoprotein, t-ag.
21855369 - A population-based study of the prevalence and sociodemographic risk factors of self-re...
8961319 - Right-left orientation, mental rotation, and perspective-taking: when can children imag...
3743689 - The single breath n2-test predicts the rate of decline in fev1. the study of men born i...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-22
Journal Detail:
Title:  Current vascular pharmacology     Volume:  -     ISSN:  1875-6212     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101157208     Medline TA:  Curr Vasc Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
James Hogg Research Centre, St. Paul's Hospital, University of British Columbia, Rm 166, Burrard Building, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada. David.Granville@hli.ubc.ca.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Novel Antiplatelet Therapy in Acute Coronary Syndromes: What is New in the Pipeline?
Next Document:  Antimicrobial Treatment to Impair Expansion of Abdominal Aortic Aneurysm (AAA): A Systematic Review ...