Document Detail


Inflaming the brain: CRPS a model disease to understand neuroimmune interactions in chronic pain.
MedLine Citation:
PMID:  23188523     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We review current concepts in CRPS from a neuroimaging perspective and point out topics and potential mechanisms that are suitable to be investigated in the next step towards understanding the pathophysiology of CRPS. We have outlined functional aspects of the syndrome, from initiating lesion via inflammatory mechanisms to CNS change and associated sickness behavior, with current evidence for up-regulation of immunological factors in CRPS, neuroimaging of systemic inflammation, and neuroimaging findings in CRPS. The initiation, maintenances and CNS targets implicated in CRPS and in the neuro-inflammatory reflex are discussed in terms of CRPS symptoms and recent preclinical studies. Potential avenues for investigating CRPS with PET and fMRI are described, along with roles of inflammation, treatment and behavior in CRPS. It is our hope that this outline will provoke discussion and promote further empirical studies on the interactions between central and peripheral inflammatory pathways manifest in CRPS.
Authors:
C Linnman; L Becerra; D Borsook
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-11-29
Journal Detail:
Title:  Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology     Volume:  8     ISSN:  1557-1904     ISO Abbreviation:  J Neuroimmune Pharmacol     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-05-23     Completed Date:  2014-02-11     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  101256586     Medline TA:  J Neuroimmune Pharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  547-63     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / immunology*,  pathology
Chronic Pain / diagnosis,  immunology*,  therapy
Complex Regional Pain Syndromes / diagnosis,  immunology*,  therapy
Comprehension*
Disease Models, Animal*
Humans
Inflammation / diagnosis,  immunology,  therapy
Neural Pathways / immunology,  pathology
Grant Support
ID/Acronym/Agency:
K24 NS064050/NS/NINDS NIH HHS; NS064050/NS/NINDS NIH HHS; R01 NS065051/NS/NINDS NIH HHS; R01NS065051/NS/NINDS NIH HHS
Comments/Corrections

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