Document Detail


Infiltrating lymphocytes in undifferentiated nasopharyngeal cancer lack metallothionein expression.
MedLine Citation:
PMID:  10814885     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Metallothionein (MT) is a metal-binding protein with functional roles in cell growth, repair and differentiation. MT is reported to be differentially expressed in lymphocytes of malignant gastrointestinal lesions. The level of MT protein was examined by immunohistochemical analysis at light microscopic and ultrastructural level in infiltrating lymphocytes from 20 cases of undifferentiated nasopharyngeal carcinoma (NPC). MT expression was found to be absent in the infiltrating lymphocytes of NPC and in reactive lymphocytes of lymphoid hyperplasia in nasopharyngeal tissues. Ultrastructural examination confirmed the absence of MT immunoreactivity in the lymphoid infiltrate of NPC. On the other hand, malignant lymphoblasts of diffuse large cell lymphoma, showed MT-immunopositivity by immunoelectron microscopy. This study demonstrates a lack of MT expression in the lymphoid stroma of undifferentiated NPC, a further characteristic of its non-neoplastic nature.
Authors:
A Jayasurya; B H Bay; W M Yap; N G Tan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer letters     Volume:  155     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-07-18     Completed Date:  2000-07-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  99-104     Citation Subset:  IM    
Affiliation:
Department of Anatomy, National University of Singapore, Singapore.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Carcinoma / metabolism,  ultrastructure
Female
Humans
Immunohistochemistry
Lymphocytes, Tumor-Infiltrating / metabolism*,  ultrastructure
Lymphoma, B-Cell / metabolism
Male
Metallothionein / biosynthesis*
Microscopy, Electron
Microscopy, Immunoelectron
Middle Aged
Nasopharyngeal Neoplasms / metabolism*,  ultrastructure
Chemical
Reg. No./Substance:
9038-94-2/Metallothionein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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