| Infertility and thyroid disorders. | |
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MedLine Citation:
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PMID: 16794427 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: This review highlights the 'gap' in knowledge regarding the contribution of thyroid dysfunction in reproduction. Thyroid dysfunction, which is quite prevalent in the population affects many organs including the male and female gonads, interferes with human reproductive physiology, reduces the likelihood of pregnancy and adversely affects pregnancy outcome, thus becoming relevant in the algorithm of reproductive dysfunction. RECENT FINDINGS: Although menstrual irregularities are common, ovulation and conception can still occur in hypothyroidism, where thyroxine treatment restores a normal menstrual pattern and reverses hormonal changes. Subclinical hypothyroidism may be associated with ovulatory dysfunction and adverse pregnancy outcome. Thyroid autoimmunity increases the miscarriage rate, and thyroxine treatment does not seem to protect. Menstrual disturbances, frequent in thyrotoxicosis are restored following treatment. In males, thyrotoxicosis has a significant but reversible effect on sperm motility. Although radioactive Iodine (I) in ablation doses may transiently affect the gonads, it does not decrease fertility or increase genetic malformation rate in the offspring. SUMMARY: Awareness of the thyroid status in the infertile couple is crucial, because of its significant, frequent and often reversible or preventable effect on infertility. Many aspects of the role of thyroid disorders however in infertility need further research. |
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Authors:
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Krinos M Trokoudes; Nicos Skordis; Michalis K Picolos |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current opinion in obstetrics & gynecology Volume: 18 ISSN: 1040-872X ISO Abbreviation: Curr. Opin. Obstet. Gynecol. Publication Date: 2006 Aug |
Date Detail:
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Created Date: 2006-06-23 Completed Date: 2006-10-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9007264 Medline TA: Curr Opin Obstet Gynecol Country: England |
Other Details:
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Languages: eng Pagination: 446-51 Citation Subset: IM |
Affiliation:
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Pedieos IVF Center, Cyprus. trokoudes@spidernet.com.cy |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Autoimmune Diseases
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complications Female Humans Infertility, Female / etiology*, therapy Infertility, Male / etiology, therapy Iodine Radioisotopes / therapeutic use Male Thyroid Diseases / complications*, therapy |
| Chemical | |
Reg. No./Substance:
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0/Iodine Radioisotopes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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