Document Detail


Infertility, infertility treatment, and congenital malformations: Danish national birth cohort.
MedLine Citation:
PMID:  16893903     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To examine whether infertile couples (with a time to pregnancy of > 12 months), who conceive naturally or after treatment, give birth to children with an increased prevalence of congenital malformations.
DESIGN: Longitudinal study.
SETTING: Danish national birth cohort.
PARTICIPANTS: Three groups of liveborn children and their mothers: 50,897 singletons and 1366 twins born of fertile couples (time to pregnancy < or = 12 months), 5764 singletons and 100 twins born of infertile couples who conceived naturally (time to pregnancy > 12 months), and 4588 singletons and 1690 twins born after infertility treatment.
MAIN OUTCOME MEASURES: Prevalence of congenital malformations determined from hospital discharge diagnoses.
RESULTS: Compared with singletons born of fertile couples, singletons born of infertile couples who conceived naturally or after treatment had a higher prevalence of congenital malformations-hazard ratios 1.20 (95% confidence interval 1.07 to 1.35) and 1.39 (1.23 to 1.57). The overall prevalence of congenital malformations increased with increasing time to pregnancy. When the analysis was restricted to singletons born of infertile couples, babies born after treatment had an increased prevalence of genital organ malformations (hazard ratio 2.32, 1.24 to 4.35) compared with babies conceived naturally. No significant differences existed in the overall prevalence of congenital malformations among twins.
CONCLUSIONS: Hormonal treatment for infertility may be related to the occurrence of malformations of genital organs, but our results suggest that the reported increased prevalence of congenital malformations seen in singletons born after assisted reproductive technology is partly due to the underlying infertility or its determinants. The association between untreated infertility and congenital malformations warrants further examination.
Authors:
Jin Liang Zhu; Olga Basso; Carsten Obel; Camilla Bille; Jørn Olsen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't     Date:  2006-08-07
Journal Detail:
Title:  BMJ (Clinical research ed.)     Volume:  333     ISSN:  1756-1833     ISO Abbreviation:  BMJ     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-09-29     Completed Date:  2006-10-12     Revised Date:  2013-06-07    
Medline Journal Info:
Nlm Unique ID:  8900488     Medline TA:  BMJ     Country:  England    
Other Details:
Languages:  eng     Pagination:  679     Citation Subset:  AIM; IM    
Affiliation:
Danish Epidemiology Science Centre, Department of Epidemiology, Institute of Public Health, University of Aarhus, DK 8000 Aarhus C, Denmark. zjl@soci.au.dk
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MeSH Terms
Descriptor/Qualifier:
Cohort Studies
Congenital Abnormalities / epidemiology*
Denmark / epidemiology
Female
Humans
Infertility / epidemiology,  therapy*
Male
Prevalence
Reproductive Techniques, Assisted / adverse effects*
Risk Factors
Comments/Corrections
Comment In:
BMJ. 2006 Sep 30;333(7570):665-6   [PMID:  17008646 ]
Republished in:
Ugeskr Laeger. 2007 Mar 5;169(10):918-20   [PMID:  17359737 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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