Document Detail


Inferior turbinate goblet cell secretion in patients with perennial allergic and nonallergic rhinitis.
MedLine Citation:
PMID:  10631405     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Perennial rhinitis is clinically associated with a significant increase in nasal mucus secretion. Moreover, it has already been established that the number of goblet cells, in the inferior turbinates of patients with perennial allergic and nonallergic rhinitis, does not differ from that of normal subjects. Thus a question is raised, whether the above-mentioned phenomenon is ascribed exclusively to submucosal glandular activity, or may also be a result of a nonhyperplastic increase of goblet cell functional activity. This study was conducted to assess inferior turbinate goblet cell mucus secretion in a cohort of patients with perennial allergic and nonallergic rhinitis compared with normal controls. A semiquantitative morphometric method was used to examine goblet cell mucus secretion in sections stained with Alcian blue and periodic acid Schiff. Mucus secretion in each section was established in terms of secretory ratio, calculated as the number of secreting goblet cells divided by the number of nonsecreting ones. The mean secretory ratio of patients with perennial allergic (n = 11) and nonallergic rhinitis (n = 23) was 0.89 and 0.57, respectively, compared to controls (n = 10) 0.25. Statistical analysis confirmed that the secretory ratio of patients with perennial allergic rhinitis was significantly higher than that of the control group. No significant difference prevailed between patients with perennial nonallergic rhinitis and controls, as well as between allergic and nonallergic patients. Based on the results of the study, a basal state of nasal goblet cell mucus secretion in nonstimulated healthy people was established. Furthermore, it was concluded that the enhancement in mucus discharge, from the inferior turbinate goblet cells of patients with perennial allergic rhinitis, was attributed to a nonhyperplastic increase of nasal goblet cell functional activity.
Authors:
G Berger; A Moroz; Z Marom; D Ophir
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  American journal of rhinology     Volume:  13     ISSN:  1050-6586     ISO Abbreviation:  Am J Rhinol     Publication Date:    1999 Nov-Dec
Date Detail:
Created Date:  2000-02-08     Completed Date:  2000-02-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8807268     Medline TA:  Am J Rhinol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  473-7     Citation Subset:  IM    
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Meir General Hospital, Kfar Saba, Israel.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Cohort Studies
Female
Goblet Cells / secretion*
Humans
Male
Nasal Lavage Fluid / cytology
Observer Variation
Probability
Reference Values
Rhinitis, Allergic, Perennial / metabolism*,  pathology*,  surgery
Sensitivity and Specificity
Turbinates / cytology,  secretion*

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