| Inference of S-system models of genetic networks by solving one-dimensional function optimization problems. | |
| | |
MedLine Citation:
|
PMID: 22155075 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Voit and Almeida have proposed the decoupling approach as a method for inferring the S-system models of genetic networks. The decoupling approach defines the inference of a genetic network as a problem requiring the solutions of sets of algebraic equations. The computation can be accomplished in a very short time, as the approach estimates S-system parameters without solving any of the differential equations. Yet the defined algebraic equations are non-linear, which sometimes prevents us from finding reasonable S-system parameters. In this study, we propose a new technique to overcome this drawback of the decoupling approach. This technique transforms the problem of solving each set of algebraic equations into a one-dimensional function optimization problem. The computation can still be accomplished in a relatively short time, as the problem is transformed by solving a linear programming problem. We confirm the effectiveness of the proposed approach through numerical experiments. |
| | |
Authors:
|
S Kimura; D Araki; K Matsumura; M Okada-Hatakeyama |
Related Documents
:
|
18796345 - An exploration of lecturer as facilitator within the context of problem-based learning. 19447005 - A new supervised learning algorithm for multiple spiking neural networks with applicati... 22255195 - Analysis of the criteria of activation-based inverse electrocardiography using convex o... 7584335 - Finding relevant biomolecular features. 16133505 - Multiple foreign body ingestion and ileal perforation. 16461465 - The kadison-singer problem in mathematics and engineering. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-12-2 |
Journal Detail:
|
Title: Mathematical biosciences Volume: - ISSN: 1879-3134 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-12-13 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0103146 Medline TA: Math Biosci Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
|
Graduate School of Engineering, Tottori University, 4-101, Koyama-minami, Tottori 680-8552, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Patient acceptable symptom state and OMERACT-OARSI set of responder criteria in joint replacement. I...
Next Document: Preoperative incisor inclination in patients with Class III dentofacial deformities treated with ort...