| Infective and inflammatory diarrhoea: mechanisms and opportunities for novel therapies. | |
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MedLine Citation:
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PMID: 21983454 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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There have been significant advances in unravelling the cellular mechanisms of diarrhoea in common gut infections and colonic inflammation, as well as in the identification of targets for potential antidiarrhoeal drugs. Infective diarrhoea reflects activation of electrogenic Cl(-) secretion, inhibition of electroneutral NaCl absorption and in some cases, downregulation of tight junctional proteins and increased apoptosis. In colonic inflammation, diarrhoea mainly reflects impairment of colonic Na(+) and Cl(-) absorption by inflammatory cytokines, leading to decreased water absorption. Stimulation of endogenous opiate-dependent pathways, manipulation of epithelial ion (Na(+), K(+) and Cl(-)) channels and suppression of proinflammatory cytokine production by a variety of drugs and novel molecules, offer opportunities to move evaluation of these potential antisecretory and anti-inflammatory agents from the laboratory into clinical trials. |
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Authors:
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Geoffrey I Sandle |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-7 |
Journal Detail:
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Title: Current opinion in pharmacology Volume: - ISSN: 1471-4973 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100966133 Medline TA: Curr Opin Pharmacol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Leeds Institute of Molecular Medicine, St James's University Hospital, Leeds LS9 7TF, United Kingdom. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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