Document Detail

Infective colitis associated with human intestinal spirochetosis.
MedLine Citation:
PMID:  17914949     Owner:  NLM     Status:  MEDLINE    
AIM: Our study reports the detection and identification of intestinal spirochetosis in patients with colonic diseases in a tertiary-care hospital over a 12-year period, and includes a description of all cases we diagnosed. METHODS: Our patients (8323) underwent colonoscopy and histopathological examinations including transmission electron microscopy (TEM) and light microscopy. Specimens from patients suspected of intestinal spirochetosis at histopathology (17 patients) underwent microbiological investigation performed by culture and molecular methods (16S restriction fragment length polymorphism-polymerase chain reaction [RFLP-PCR], nox RFLP-PCR assays). RESULTS: Seventeen cases were diagnosed: seven patients were infected by B. aalborgi, one by B. pilosicoli, two by both species and four by Brachyspira spp. diagnosed both histopathology and microbiology (culture and molecular methods: 16S RFLP-PCR and nox RFLP-PCR assays). Three cases were referred to as Brachyspira spp. infections using only histopathology, including TEM. CONCLUSIONS: Our results demonstrated that intestinal spirochetosis, although rarely occurring, might play a role in chronic diarrhea and suggested a pathogenetic mechanism of intestinal spirochetosis based on the destruction of colonic microvilli and colitis histologically documented, providing additional clinical and pathological information on this entity. This study suggests that metronidazole seems to be the drug of choice for the eradication of intestinal spirochetosis.
Adriana Calderaro; Simona Bommezzadri; Chiara Gorrini; Giovanna Piccolo; Simona Peruzzi; Vincenzo Villanacci; Claudia Zambelli; Giuseppe Dettori; Carlo Chezzi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of gastroenterology and hepatology     Volume:  22     ISSN:  0815-9319     ISO Abbreviation:  J. Gastroenterol. Hepatol.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-04     Completed Date:  2008-01-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8607909     Medline TA:  J Gastroenterol Hepatol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  1772-9     Citation Subset:  IM    
Department of Pathology and Laboratory Medicine, Section of Microbiology, University of Parma, Parma, Italy.
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MeSH Terms
Anti-Bacterial Agents / therapeutic use
Brachyspira* / genetics,  ultrastructure
Child, Preschool
Colitis / microbiology*,  pathology
Colon / microbiology*,  ultrastructure
DNA, Bacterial / analysis
Intestinal Mucosa / microbiology
Metronidazole / therapeutic use
Microscopy, Electron, Transmission
Microvilli / microbiology
Middle Aged
Spirochaetales* / genetics,  ultrastructure
Spirochaetales Infections / complications*,  microbiology,  pathology
Treatment Outcome
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/DNA, Bacterial; 443-48-1/Metronidazole
Erratum In:
J Gastroenterol Hepatol. 2007 Nov;22(11):2049

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