| Infectious port complications are more frequent in younger patients with hematologic malignancies than in solid tumor patients. | |
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MedLine Citation:
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PMID: 18716418 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: We assessed longevity and complications of totally implantable venous access devices in oncology patients. METHODS: 197 patients received a total of 201 port devices via the subclavian vein for delivery of chemotherapy between January 1, 2005, and December 31, 2006. We reviewed the patient charts for port-related complications and risk factors until July 31, 2007. RESULTS: A total of 47,781 catheter days were analyzed (median, 175 days; range, 1-831). Forty-six different complications occurred (0.96 complications/1,000 catheter days). The only risk factor significantly associated with a higher complication rate was younger age. Older patients had a lower risk for developing complications with a risk reduction of 2.4% for each year. There were no differences regarding underlying tumor, gender, access side, method of placement (subclavian/cephalic vein) or implanting team (thoracic versus visceral surgery). A trend was seen for shorter port longevity in hematologic patients compared to oncologic patients (p = 0.059). The former developed significantly more port-associated infections than solid tumor patients [11/53 cases (21%) versus 2/148 cases (1.4%); p < 0.0001]. CONCLUSIONS: Port-associated infections were mostly observed in younger patients with hematologic neoplasms. Prospective trials should be performed to evaluate the benefit of a prophylactic antimicrobial lock in these selected patients. |
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Authors:
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Panagiotis Samaras; Stefan Dold; Julia Braun; Peter Kestenholz; Stefan Breitenstein; Alexander Imhof; Christoph Renner; Frank Stenner-Liewen; Bernhard C Pestalozzi |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2008-08-21 |
Journal Detail:
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Title: Oncology Volume: 74 ISSN: 1423-0232 ISO Abbreviation: Oncology Publication Date: 2008 |
Date Detail:
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Created Date: 2008-09-05 Completed Date: 2008-10-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0135054 Medline TA: Oncology Country: Switzerland |
Other Details:
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Languages: eng Pagination: 237-44 Citation Subset: IM |
Copyright Information:
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(c) 2008 S. Karger AG, Basel. |
Affiliation:
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Department of Oncology, University Hospital Zürich, Zürich, Switzerland. panagiotis.samaras@usz.ch |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Age Factors Aged Aged, 80 and over Antineoplastic Agents / administration & dosage Catheterization, Central Venous / instrumentation* Catheters, Indwelling / microbiology* Equipment Contamination* Female Follow-Up Studies Hematologic Neoplasms / complications*, therapy Humans Male Middle Aged Neoplasms / complications*, therapy Prosthesis-Related Infections / etiology* Retrospective Studies Risk Factors Survival Rate |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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