Document Detail

Infectious port complications are more frequent in younger patients with hematologic malignancies than in solid tumor patients.
MedLine Citation:
PMID:  18716418     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: We assessed longevity and complications of totally implantable venous access devices in oncology patients. METHODS: 197 patients received a total of 201 port devices via the subclavian vein for delivery of chemotherapy between January 1, 2005, and December 31, 2006. We reviewed the patient charts for port-related complications and risk factors until July 31, 2007. RESULTS: A total of 47,781 catheter days were analyzed (median, 175 days; range, 1-831). Forty-six different complications occurred (0.96 complications/1,000 catheter days). The only risk factor significantly associated with a higher complication rate was younger age. Older patients had a lower risk for developing complications with a risk reduction of 2.4% for each year. There were no differences regarding underlying tumor, gender, access side, method of placement (subclavian/cephalic vein) or implanting team (thoracic versus visceral surgery). A trend was seen for shorter port longevity in hematologic patients compared to oncologic patients (p = 0.059). The former developed significantly more port-associated infections than solid tumor patients [11/53 cases (21%) versus 2/148 cases (1.4%); p < 0.0001]. CONCLUSIONS: Port-associated infections were mostly observed in younger patients with hematologic neoplasms. Prospective trials should be performed to evaluate the benefit of a prophylactic antimicrobial lock in these selected patients.
Panagiotis Samaras; Stefan Dold; Julia Braun; Peter Kestenholz; Stefan Breitenstein; Alexander Imhof; Christoph Renner; Frank Stenner-Liewen; Bernhard C Pestalozzi
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2008-08-21
Journal Detail:
Title:  Oncology     Volume:  74     ISSN:  1423-0232     ISO Abbreviation:  Oncology     Publication Date:  2008  
Date Detail:
Created Date:  2008-09-05     Completed Date:  2008-10-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0135054     Medline TA:  Oncology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  237-44     Citation Subset:  IM    
Copyright Information:
(c) 2008 S. Karger AG, Basel.
Department of Oncology, University Hospital Zürich, Zürich, Switzerland.
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MeSH Terms
Age Factors
Aged, 80 and over
Antineoplastic Agents / administration & dosage
Catheterization, Central Venous / instrumentation*
Catheters, Indwelling / microbiology*
Equipment Contamination*
Follow-Up Studies
Hematologic Neoplasms / complications*,  therapy
Middle Aged
Neoplasms / complications*,  therapy
Prosthesis-Related Infections / etiology*
Retrospective Studies
Risk Factors
Survival Rate
Reg. No./Substance:
0/Antineoplastic Agents

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