Document Detail

Infectious complications associated with the use of acellular dermal matrix in implant-based bilateral breast reconstruction.
MedLine Citation:
PMID:  22531395     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: : The use of acellular dermal matrix (ADM) has become a routine practice in implant-based breast reconstruction. Bilateral mastectomy is becoming more popular in cases of unilateral breast cancer. ADM has been associated with an increased incidence of complications.
METHODS: : We identified cases of bilateral implant-based breast reconstruction over a 5-year period. Data collection included medical comorbities, details of operative management, and details of postoperative cancer treatment.
RESULTS: : On univariate analysis, the use of ADM (31% vs. 7%, P = 0.018), smoking (37% vs. 13%, P = 0.045), and open wound (55% vs. 13%, P = 0.006) were significantly associated with increased risk of infection. Multivariate analysis revealed open wound as the strongest predictor of infection.
CONCLUSIONS: : The use of ADM is associated with an increased risk of infection in bilateral implant-based breast reconstruction. However, it does not appear to be an independent risk factor by itself.
Joseph L Hill; Lesley Wong; Pamela Kemper; Jason Buseman; Daniel L Davenport; Henry C Vasconez
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of plastic surgery     Volume:  68     ISSN:  1536-3708     ISO Abbreviation:  Ann Plast Surg     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7805336     Medline TA:  Ann Plast Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  432-4     Citation Subset:  IM    
From the Division of Plastic Surgery, University of Kentucky College of Medicine, Lexington, KY.
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