Document Detail

Infectious mononucleosis in university students in the United kingdom: evaluation of the clinical features and consequences of the disease.
MedLine Citation:
PMID:  20121570     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Infectious mononucleosis (IM) is common among university students. We undertook to analyze the clinical features and sequelae of the disease in a cohort of students at Edinburgh University. METHODS: Consecutive IM case patients were recruited from 2000 through 2002 at the University Health Service after diagnosis of IM. RESULTS: IM resulted in marked reductions in student study time, physical exercise, and non-exercise-related social activities, and sustained increases in reported number of hours of sleep. The disease profile differed between the sexes, with significantly more females reporting fatigue, which was more likely to be prolonged (P = .003) and to lead to loss of study time (P = .013). Female case patients were more likely to discontinue their studies following IM (16% vs 0%; P = .056). Within the typically elevated lymphocyte counts in IM, we identified an elevated gammadelta T cell component that may contribute to the disease pathogenesis. CONCLUSIONS: IM results in substantial morbidity among university students, reported as more profound in females, and affecting academic studies, physical exercise, and social activities. Immunization to prevent IM and strategies to reduce post-IM disability would be beneficial in this population.
Karen F Macsween; Craig D Higgins; Karen A McAulay; Hilary Williams; Nadine Harrison; Anthony J Swerdlow; Dorothy H Crawford
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America     Volume:  50     ISSN:  1537-6591     ISO Abbreviation:  Clin. Infect. Dis.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-08     Completed Date:  2010-04-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9203213     Medline TA:  Clin Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  699-706     Citation Subset:  IM    
Department of Clinical and Molecular Virology, University of Edinburgh, Summerhall, United Kingdom.
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MeSH Terms
Great Britain / epidemiology
Infectious Mononucleosis / epidemiology*,  pathology*
Learning Disorders
Sex Factors
Social Behavior
Treatment Outcome
Young Adult
Grant Support
G9826804//Medical Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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