| Infectious Keratitis in Severe Limbal Stem Cell Deficiency: Characteristics and Risk Factors. | |
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MedLine Citation:
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PMID: 22537286 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Purpose: To evaluate the incidence, clinical and microbiological characteristics and risk factors of infectious keratitis in patients with limbal stem cell deficiency (LSCD). Methods: Retrospective comparative case series of 35 patients with severe LSCD. Results: The mean follow-up time was 46 months. Infectious keratitis were mainly caused by Gram positive bacteria (94%). Only 7 infections (37%) healed under fortified adapted antibiotics. In 8 cases (42%), amniotic membrane transplantation was required and in 4 cases (21%) «à chaud» keratoplasty was performed. Significant risk factors associated with infectious keratitis were: soft contact lens extended wear, history of persistent epithelial defects, number of quadrants of corneal vascularization, re-epithelialization time after amniotic membrane or corneal transplantation, and use of corticosteroid or cyclosporin eye drops. Conclusion: Infectious keratitis in LSCD is frequent and severe. The restoration of the epithelial barrier integrity and a careful use of therapeutic contact lenses may help to prevent infection. |
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Authors:
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Otman Sandali; Thomas Gaujoux; Pablo Goldschmidt; Djida Ghoubay-Benallaoua; Laurent Laroche; Vincent M Borderie |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-4-26 |
Journal Detail:
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Title: Ocular immunology and inflammation Volume: - ISSN: 1744-5078 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-4-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9312169 Medline TA: Ocul Immunol Inflamm Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Centre Hospitalier National d'Ophtalmologie des XV-XX, Pierre & Marie Curie University Paris 06 , Research team 968, Institut de la Vision, Paris , France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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