Document Detail

Infectious crystalline keratopathy caused by Streptococcus Abiotrophia defectiva.
MedLine Citation:
PMID:  20508513     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To report the first case of Streptococcus Abiotrophia defectiva-associated crystalline keratopathy. METHODS: An 83-year-old woman underwent penetrating keratoplasty for pseudophakic bullous keratopathy in the OD. Ten months after surgery, the patient presented with decreased visual acuity in the OD. Slit-lamp examination showed crystalline keratopathy. Corneal scrapings were negative, and the patient was treated empirically with 2 fortified antibiotics (ciprofloxacin and vancomycin). Despite these treatments, the surface of the infiltrate increased and corneal regrafting was performed 6 weeks later. The excised prior graft was evaluated microbiologically [culture and polymerase chain reaction (PCR)] and histopathologically. RESULTS: In the explanted corneal graft, cultures grew Streptococcus A. defectiva, and its DNA was demonstrated by broad-range PCR (16S ribosomal DNA). CONCLUSIONS: A. defectiva can be a causative organism of infectious crystalline keratopathy. Risk factors may include long-term corticosteroid use and prior corneal transplantation. The present case confirms that PCR can be a useful technique in the diagnosis of deep infectious keratitis.
Florence Abry; Arnaud Sauer; Philippe Riegel; Maher Saleh; David Gaucher; Claude Speeg-Schatz; Tristan Bourcier
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cornea     Volume:  29     ISSN:  1536-4798     ISO Abbreviation:  Cornea     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-27     Completed Date:  2010-10-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8216186     Medline TA:  Cornea     Country:  United States    
Other Details:
Languages:  eng     Pagination:  934-6     Citation Subset:  IM    
Department of Ophthalmology, University Hospital of Strasbourg, Strasbourg, France.
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MeSH Terms
Aged, 80 and over
Anti-Bacterial Agents / therapeutic use
Bacterial Typing Techniques
Corneal Ulcer / diagnosis,  microbiology*,  surgery
DNA, Bacterial / analysis
Drug Therapy, Combination
Eye Infections, Bacterial / diagnosis,  microbiology*,  surgery
Keratoplasty, Penetrating
Microbial Sensitivity Tests
Polymerase Chain Reaction
RNA, Ribosomal, 16S / genetics
Streptococcal Infections / diagnosis,  microbiology*,  surgery
Streptococcus / genetics,  isolation & purification*
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/DNA, Bacterial; 0/RNA, Ribosomal, 16S

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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