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Infectious Burden of Respiratory Syncytial Virus in Relation to Time of Birth Modifies the Risk of Lower Respiratory Tract Infection in Infancy: The Norwegian Mother and Child Cohort.
MedLine Citation:
PMID:  23385949     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE:: The risk of respiratory syncytial virus (RSV) infection according to calendar month of birth has previously been demonstrated. We hypothesize that the real-time infectious burden (IB) of RSV, in relation to time and county of birth, modifies the risk of LRTI in infants, an association that has not been investigated previously, and may be used as an alternative measure of RSV risk when drafting RSV immunoprophylaxis guidelines. METHODS:: 30087 pregnancies were included from July 1st 2003 to July 31st 2006. IB was defined by month and county as the number of RSV detections per inhabitant. IB for 5 periods ante- and postnatally was calculated for each child. Outcome variables were maternally reported hospitalization for LRTI before age 6 months and. LRTI before age 12 months. Logistic regression was used to estimate associations between IB and LRTI. RESULTS:: The odds of hospitalization for LRTI rise with increased IB the first 3 months after birth. Low IB: OR 1.17 (95% CI 0.98 - 1.39); Medium IB: OR 1.42 (95% CI 1.21 - 1.68); High IB: OR 2.51 (95% CI 2.15 - 2.94). High IB 3-0 months before birth confers a lower odds of hospitalization for LRTI the first 6 months of life, OR 0.51 (95% CI 0.43 - 0.61). Similar results were seen for maternally reported LRTI the first 12 months of life. CONCLUSIONS:: We find an association between real-time RSV infectious burden and LRTI in infancy: high burden prior to birth is protective and high burden after birth increases the risk.
Authors:
Ida Monn Birkhaug; Christopher Stephen Inchley; Geir Aamodt; Gabriel Anestad; Wenche Nystad; Britt Nakstad
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-4
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  -     ISSN:  1532-0987     ISO Abbreviation:  Pediatr. Infect. Dis. J.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1) Department of Pediatrics, Akershus University Hospital, Norway 2) Faculty Division Akershus University Hospital, University of Oslo, Norway 3) Division of Epidemiology, Norwegian Institute of Public Health, Norway 4) Department of Mathematical Sciences and Technology, Norwegian University of Life Sciences, Norway 5) Department of Virology, Norwegian Institute of Public Health, Norway.
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