Document Detail

Infections and immunological hazards of allogeneic bone transplantation.
MedLine Citation:
PMID:  7619637     Owner:  NLM     Status:  MEDLINE    
Allogeneic transplantation of human cancellous and cortical bone is a controversially discussed concept in trauma and orthopaedic surgery. Biological and immunological arguments support transplantation of autologous material whenever this is technically possible. On the other hand, synthetic alloplastic materials for bone substitution are available free of immunological and hygienic hazards. In this context the value of allogeneic bone grafts is discussed, especially considering the problem of AIDS. If autologous corticospongious bone is to be used its supply is limited. On the other hand, alloplastic synthetic artificial bone does not meet all the requirements demanded for substitution of large osseous defects up to now. The problems of geometric and mechanical stability of these alloplastic materials still remain. Therefore, no alternative to allografting of large, stable, corticospongious fragments exists in some cases. Bone transplantation is performed without vital indication in nearly every case. Thus an optimum of hygienic security has to be claimed for recipients of allogeneic bone. The "Munich model" for bone transplantation is presented and discussed.
G O Hofmann; M H Kirschner; T Wangemann; C Falk; W Mempel; C Hammer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Archives of orthopaedic and trauma surgery     Volume:  114     ISSN:  0936-8051     ISO Abbreviation:  Arch Orthop Trauma Surg     Publication Date:  1995  
Date Detail:
Created Date:  1995-08-28     Completed Date:  1995-08-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9011043     Medline TA:  Arch Orthop Trauma Surg     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  159-66     Citation Subset:  IM; X    
Chirurgische Klinik und Poliklinik, Ludwig-Maximilians-Universität, Klinikum Grosshadern, München, Germany.
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MeSH Terms
Acquired Immunodeficiency Syndrome / transmission
Bone Transplantation* / adverse effects,  contraindications,  immunology,  standards
Communicable Diseases / transmission
Graft Survival
Transplantation Immunology*
Transplantation, Homologous

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