Document Detail

Infection with human coronavirus NL63 enhances streptococcal adherence to epithelial cells.
MedLine Citation:
PMID:  21325482     Owner:  NLM     Status:  MEDLINE    
Understanding the mechanisms of augmented bacterial pathogenicity in post-viral infections is the first step in the development of an effective therapy. This study assessed the effect of human coronavirus NL63 (HCoV-NL63) on the adherence of bacterial pathogens associated with respiratory tract illnesses. It was shown that HCoV-NL63 infection resulted in an increased adherence of Streptococcus pneumoniae to virus-infected cell lines and fully differentiated primary human airway epithelium cultures. The enhanced binding of bacteria correlated with an increased expression level of the platelet-activating factor receptor (PAF-R), but detailed evaluation of the bacterium-PAF-R interaction revealed a limited relevance of this process.
Anna Golda; Natalia Malek; Bartosz Dudek; Slawomir Zeglen; Jacek Wojarski; Marek Ochman; Ewa Kucewicz; Marian Zembala; Jan Potempa; Krzysztof Pyrc
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-02-16
Journal Detail:
Title:  The Journal of general virology     Volume:  92     ISSN:  1465-2099     ISO Abbreviation:  J. Gen. Virol.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-17     Completed Date:  2011-07-12     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  0077340     Medline TA:  J Gen Virol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1358-68     Citation Subset:  IM    
Microbiology Department, Faculty of Biochemistry Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.
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MeSH Terms
Bacterial Adhesion*
Cell Line
Cells, Cultured
Coronavirus NL63, Human / physiology*
Epithelial Cells / metabolism,  microbiology*,  virology*
Gene Expression
Platelet Membrane Glycoproteins / genetics,  metabolism
Receptors, G-Protein-Coupled / genetics,  metabolism
Respiratory Tract Infections / genetics,  metabolism,  microbiology*,  virology*
Streptococcus / physiology*
Grant Support
Reg. No./Substance:
0/Platelet Membrane Glycoproteins; 0/Receptors, G-Protein-Coupled; 0/platelet activating factor receptor

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