| Infection and rheumatoid arthritis: still an open question. | |
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MedLine Citation:
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PMID: 21532483 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: This review focuses on recent research that explores the role of infectious organisms in the development of autoimmunity and rheumatoid arthritis (RA). RECENT FINDINGS: Human and animal studies provide further evidence supporting a role for the periodontal pathogen, Porphyromonas gingivalis, in the development of RA. The microbiome plays a key role in the developing immune system. Alterations in the bowel microbiome lead to altered innate and adaptive immune responses potentially relevant to the development or persistence of RA. SUMMARY: Microbes and the host response to microbes are important factors in the maintenance of health. Abnormalities or imbalances in these responses can lead to the development of autoimmune inflammatory conditions such as RA. |
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Authors:
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Carol A Hitchon; Hani S El-Gabalawy |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-29 |
Journal Detail:
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Title: Current opinion in rheumatology Volume: - ISSN: 1531-6963 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-5-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9000851 Medline TA: Curr Opin Rheumatol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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University of Manitoba, Winnipeg, Manitoba, Canada. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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