Document Detail

Infection resistance of unreamed solid, hollow slotted and cannulated intramedullary nails: an in-vivo experimental comparison.
MedLine Citation:
PMID:  16022994     Owner:  NLM     Status:  MEDLINE    
Infection continues to be a problematic complication of fracture treatment, particularly in severe open fractures. The implant design and material as well as implantation technique play an important role in the pathogenesis of local infection. The aim of our study was to determine if the local resistance to infection of a cannulated IM nail is less than that of a solid nail and more similar to that of a hollow nail. In 65 female White Zealand rabbits, the intramedullary cavity was inoculated with matching concentrations of Staphylococcus aureus, and one of the three nails was inserted. The solid nail had a greater than twofold higher resistance to infection (23%) compared to that of the other two nails (hollow, 65%; cannulated, 61%) which was statistically significant (p<0.02). No difference in infection resistance was detected between the hollow slotted and cannulated nail designs (p=1). Although these experimental results may be clinically considered, direct extrapolation to clinical infection rates is ill advised.
J Horn; U Schlegel; C Krettek; K Ito
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Publication Detail:
Type:  Journal Article     Date:  2005-01-18
Journal Detail:
Title:  Journal of orthopaedic research : official publication of the Orthopaedic Research Society     Volume:  23     ISSN:  0736-0266     ISO Abbreviation:  J. Orthop. Res.     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-07-18     Completed Date:  2005-08-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8404726     Medline TA:  J Orthop Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  810-5     Citation Subset:  IM    
AO Research Institute, Clavadelerstrasse, 7270 Davos Platz, Davos, Switzerland.
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MeSH Terms
Bone Nails*
Fracture Fixation, Internal*
Osteomyelitis / microbiology,  prevention & control*,  radiography
Postoperative Complications / microbiology,  prevention & control
Prosthesis Design
Staphylococcal Infections / prevention & control*,  radiography
Tibial Fractures / radiography,  surgery*

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