Document Detail

Infection-related hospitalization rates in pediatric versus adult patients with end-stage renal disease in the United States.
MedLine Citation:
PMID:  17251389     Owner:  NLM     Status:  MEDLINE    
Infection is a common cause of morbidity and mortality in patients with ESRD. Infection-related hospitalization (IH) incidence among US Medicare incident pediatric and adult dialysis and transplant patients within 3 yr of presentation was compared from 1996 to 2001: Hemodialysis (HD) patients (pediatric n = 1469; adult n = 305,323); peritoneal dialysis (PD) patients (pediatric n=982; adult n=27,119), and kidney transplant (KTx) patients (pediatric n=1108; adult n=31,663). IH were identified from principal diagnosis codes; IH cumulative incidence and rates were calculated from claims data. Cumulative incidence of IH at 36 mo for incident pediatric patients with ESRD during 1996 to 2001 was 39.9% in HD, 51.2% in PD, and 47.4% in KTx patients (HD or PD versus KTx, P<0.0001). Cumulative incidence for adults was 52.6% in HD, 51.8% in PD, and 39.8% in KTx patients (HD or PD versus KTx, P<0.0001). IH rates per 1000 patient-months were highest for pediatric KTx patients (adjusted rate ratio 1.53 versus HD and 1.90 versus PD, P<0.001 for each) and adult HD patients (adjusted rate ratio 1.20 versus KTx and 1.11 versus PD, P < 0.001 for each). Within the first 36 mo of incidence, IH rates are highest for incident pediatric KTx patients compared with HD and PD patients, in contrast to findings for adult patients with ESRD. Pediatric KTx patients require infection surveillance after transplantation.
Blanche M Chavers; Craig A Solid; David T Gilbertson; Allan J Collins
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2007-01-24
Journal Detail:
Title:  Journal of the American Society of Nephrology : JASN     Volume:  18     ISSN:  1046-6673     ISO Abbreviation:  J. Am. Soc. Nephrol.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-02-28     Completed Date:  2007-07-24     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  9013836     Medline TA:  J Am Soc Nephrol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  952-9     Citation Subset:  IM    
University of Minnesota, Department of Pediatrics, Mayo Mail Code 491, 420 Delaware Street SE, Minneapolis, MN 5545, USA.
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MeSH Terms
Age Factors
Aged, 80 and over
Child, Preschool
Databases, Factual
Hospital Mortality
Hospitalization / statistics & numerical data*
Infection / epidemiology*,  etiology
Kidney Failure, Chronic / complications*,  mortality
Kidney Transplantation / adverse effects*
Middle Aged
Renal Dialysis / adverse effects*
United States / epidemiology
Urinary Tract Infections / epidemiology
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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