Document Detail

Infection, neutrophils, and hematopoietic growth factors in the pathogenesis of neonatal chronic lung disease.
MedLine Citation:
PMID:  10986637     Owner:  NLM     Status:  MEDLINE    
Continued definition of the biochemical and molecular mechanisms underlying the development of chronic lung disease (CLD) has persuaded investigators that inflammatory cells and mediators are key factors in the pathophysiology of the disease. High numbers of inflammatory cells and their products are present in the airways of ventilated neonates with respiratory distress syndrome and precede the development of CLD. This article reviews the mechanisms underlying neutrophil recruitment in the lungs of ventilated preterm infants with respiratory distress syndrome and the injurious effects that these cells can produce on lung parenchyma with special emphasis on the development of CLD. The role of granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor is stressed as a pivotal mechanism of neutrophil recruitment and activation.
P Papoff
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinics in perinatology     Volume:  27     ISSN:  0095-5108     ISO Abbreviation:  Clin Perinatol     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2000-12-04     Completed Date:  2000-12-14     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7501306     Medline TA:  Clin Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  717-31, viii     Citation Subset:  IM    
Department of Pediatrics, University La Sapienza, Rome, Italy.
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MeSH Terms
Chronic Disease
Hematopoietic Cell Growth Factors / physiology*
Infant, Newborn
Infection / complications*
Lung Diseases / etiology*,  microbiology*
Neutrophils / physiology*
Reg. No./Substance:
0/Hematopoietic Cell Growth Factors

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