Document Detail

Infection in knee replacements after previous injection of intra-articular steroid.
MedLine Citation:
PMID:  16498004     Owner:  NLM     Status:  MEDLINE    
We reviewed 231 patients who had undergone total knee replacement with an AGC (Biomet) implant over a period of 2.5 years. After applying exclusion criteria and with some loss to follow-up, there were 144 patients available for study. These were divided into two groups; those who had received intra-articular steroid in the 11 months before surgery and those who had not. There were three deep infections, all of which occurred in patients who had received a steroid injection. The incidence of superficial infection was not significantly different in the two groups. Five patients had undergone investigation for suspected deep infection because of persistent swelling or pain and all of these had received an intra-articular injection pre-operatively. We conclude that the decision to administer intra-articular steroids to a patient who may be a candidate for total knee replacement should not be taken lightly because of a risk of post-operative deep infection.
A V Papavasiliou; D L Isaac; R Marimuthu; A Skyrme; A Armitage
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of bone and joint surgery. British volume     Volume:  88     ISSN:  0301-620X     ISO Abbreviation:  J Bone Joint Surg Br     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-02-24     Completed Date:  2006-04-27     Revised Date:  2010-11-10    
Medline Journal Info:
Nlm Unique ID:  0375355     Medline TA:  J Bone Joint Surg Br     Country:  England    
Other Details:
Languages:  eng     Pagination:  321-3     Citation Subset:  AIM; IM    
Orthopaedic Department, Eastbourne District General Hospital NHS Trust, Kings Drive, Eastbourne BN21 2UD, UK.
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MeSH Terms
Aged, 80 and over
Anti-Bacterial Agents / therapeutic use
Arthroplasty, Replacement, Knee*
Injections, Intra-Articular / adverse effects
Knee Prosthesis / adverse effects*
Middle Aged
Osteoarthritis, Knee / complications,  surgery
Prosthesis-Related Infections / chemically induced*,  drug therapy
Retrospective Studies
Steroids / administration & dosage,  adverse effects*
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Steroids
Comment In:
J Bone Joint Surg Br. 2007 Mar;89(3):422-3; author reply 423   [PMID:  17356166 ]
J Bone Joint Surg Br. 2007 Mar;89(3):422; author reply 422   [PMID:  17356167 ]
J Bone Joint Surg Br. 2007 Mar;89(3):423; author reply 423   [PMID:  17356168 ]

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