Document Detail

Infection of human amnion cells with cytomegalovirus.
MedLine Citation:
PMID:  215716     Owner:  NLM     Status:  MEDLINE    
Human cytomegalovirus (CMV), known to replicate in vitro in human fibroblastic cells, was found to replicate in epithelial human amnion (HA) cells. Large syncytia formed in these cells after infection with CMV; inclusion bodies were observed in the nuclei, and CMV antigens were demonstrated in both the cytoplasm and the nucleus by indirect immunofluorescence techniques. The synthesis of virus DNA was also detected, and the production of infectious virus was followed. The titers were lower (from 10(4) to 6 X 10(5) using different isolates of CMV) than those obtained in human embryo fibroblast (HEF) cells, and the replication cycle was slower in HA than in HEF cells.
M E Figueroa; L Geder; F Rapp
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of medical virology     Volume:  2     ISSN:  0146-6615     ISO Abbreviation:  J. Med. Virol.     Publication Date:  1978  
Date Detail:
Created Date:  1979-03-28     Completed Date:  1979-03-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7705876     Medline TA:  J Med Virol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  369-75     Citation Subset:  IM    
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MeSH Terms
Antigens, Viral / analysis
Cell Nucleus / microbiology
Culture Techniques
Cytomegalovirus / growth & development*,  immunology
Cytopathogenic Effect, Viral
Epithelium / microbiology*
Fibroblasts / microbiology
Inclusion Bodies, Viral
Virus Replication
Reg. No./Substance:
0/Antigens, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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