| Infection of dendritic cells with herpes simplex virus type 1 induces rapid degradation of CYTIP, thereby modulating adhesion and migration. | |
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MedLine Citation:
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PMID: 21562043 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Immune responses require spatial and temporal coordinated interactions between different cell types within distinct microenvironments. This dynamic interplay depends on the competency of the involved cells, predominantly leukocytes, to actively migrate to defined sites of cellular encounters in various tissues. Due to their unique capacity to transport antigen from the periphery to secondary lymphoid tissues for the activation of naïve T-cells, dendritic cells (DCs) play a key role in the initiation and orchestration of adaptive immune responses. Therefore, pathogen-mediated interference with this process is a very effective way of immune-evasion. CYTIP (cytohesin-interacting protein) is a key regulator of DC motility. It has previously been described to control LFA-1 deactivation and to regulate DC adherence. CYTIP expression is upregulated during DC maturation, enabling their transition from the sessile to the motile state. Here, we demonstrate that upon infection of human monocyte-derived DCs with herpes simplex virus type 1 (HSV-1), CYTIP is rapidly degraded and as a consequence beta-2 integrins, predominantly LFA-1, are activated. Furthermore we show that the impairment of migration in HSV-1-infected DCs is in part due to this increased integrin-mediated adhesion. Thus, we propose a new mechanism of pathogen-interference with central aspects of leukocyte biology. |
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Authors:
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Alexandros A Theodoridis; Christina Eich; Carl G Figdor; Alexander Steinkasserer |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-11 |
Journal Detail:
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Title: Blood Volume: - ISSN: 1528-0020 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7603509 Medline TA: Blood Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Immune Modulation at the Department of Dermatology, University Hospital Erlangen, Erlangen, Germany; |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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