Document Detail

Infection and cancer following renal transplantation.
MedLine Citation:
PMID:  16903626     Owner:  NLM     Status:  MEDLINE    
Ever increasingly potent but non-specific immunosuppression has necessarily brought with it the continuing risk of opportunistic infections and virus-induced malignancies. The improvement in graft and patient survival rates from transplantation has depended to a certain extent on parallel improvements in the diagnosis and treatment of infectious complications. This review will highlight some of the current problems and progress. The risks of infection are largely related to the total burden of immunosuppression rather than any particular drug, although sirolimus and the anti CD25 antibodies may be an exception. Almost all the post-transplant infections are treatable; a precise microbiological diagnosis is essential so that specific therapy can be used. Newer molecular diagnostic techniques are increasingly widely available, e.g.quantitative polymerase chain reaction. The transplant community will inevitably be faced with highly resistant bacteria such as. Methicillin resistant Staphylococcus Aureus (MRSA) and will have to develop appropriate strategies. New infectious organisms continue to be identified [e.g. Burkitt's Virus (BKV), West Nile virus and Avian influenza) and will continue to tax the ingenuity of transplant physicians and microbiologists.
Paul Sweny
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia     Volume:  17     ISSN:  1319-2442     ISO Abbreviation:  Saudi J Kidney Dis Transpl     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-08-14     Completed Date:  2006-10-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9436968     Medline TA:  Saudi J Kidney Dis Transpl     Country:  Saudi Arabia    
Other Details:
Languages:  eng     Pagination:  189-99     Citation Subset:  IM    
Royal Free Hospital, London, United Kingdom.
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MeSH Terms
Antiviral Agents / therapeutic use
BK Virus / pathogenicity
Bacterial Infections / etiology
Cytomegalovirus Infections / etiology
Infection / diagnosis,  etiology*
Kidney Transplantation / adverse effects*
Lymphoproliferative Disorders / virology
Mycoses / etiology
Neoplasms / virology*
Neoplasms, Squamous Cell / virology
Postoperative Complications*
Sarcoma, Kaposi / etiology
Urinary Tract Infections / etiology
Reg. No./Substance:
0/Antiviral Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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