Document Detail

Infection, oxygen, and immaturity: interacting risk factors for retinopathy of prematurity.
MedLine Citation:
PMID:  20733333     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Interactions among known risk factors for retinopathy of prematurity (ROP) remain to be clarified.
OBJECTIVES: The aim of this study was to identify risk factors associated with ROP and to explore the interrelationships between prominent risk factors for ROP.
METHODS: From an institutional cohort of 1,646 very preterm newborns with gestational age <30 weeks or birth weight <1,501 g, we selected infants with a gestational age <30 weeks who met the criteria for ROP screening (n = 622) for a nested case-control analysis.
RESULTS: Of the 622 eligible newborns, 293 (47%) were diagnosed with ROP. From multivariable analyses, gestational age <26 weeks (OR 2.9, CI 1.7-4.9), oxygen exposure at 28 days (OR 1.7, CI 1.0-2.7), and neonatal sepsis (OR 2.1, CI 1.4-3.2) emerged as prominent risk factors for ROP. Oxygen- associated ROP risk was more prominent among infants of 23-25 weeks' gestational age, while infection-associated ROP risk was higher among infants born at 28-29 weeks. The OR for the joint effect of all 3 risk factors (23.5) was higher than would have been expected under the additive (8.6) and the multiplicative (16.5) patterns of interaction.
CONCLUSIONS: Our study suggests that neonatal sepsis, oxygen exposure, and low gestational age are not only independently associated with a significantly increased risk of ROP, but also interact beyond additive and even multiplicative patterns.
Minghua Chen; Ayse Citil; Frank McCabe; Katherine M Leicht; John Fiascone; Christiane E L Dammann; Olaf Dammann
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-08-24
Journal Detail:
Title:  Neonatology     Volume:  99     ISSN:  1661-7819     ISO Abbreviation:  Neonatology     Publication Date:  2011  
Date Detail:
Created Date:  2011-02-04     Completed Date:  2011-06-14     Revised Date:  2011-07-25    
Medline Journal Info:
Nlm Unique ID:  101286577     Medline TA:  Neonatology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  125-32     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 S. Karger AG, Basel.
Division of Newborn Medicine, Floating Hospital for Children at Tufts Medical Center, Boston, MA 02111-1526, USA.
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MeSH Terms
Case-Control Studies
Cohort Studies
Gestational Age
Infant, Newborn
Infant, Premature / physiology*
Logistic Models
Oxygen Inhalation Therapy / adverse effects*
Prospective Studies
Retinopathy of Prematurity / etiology*,  immunology
Sepsis / immunology
Grant Support
1R21EY019253-01/EY/NEI NIH HHS

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